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Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.
Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Krueger AB, et al. Among authors: holliday mj. J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22. J Biol Chem. 2014. PMID: 24755226 Free PMC article.
Networks of Dynamic Allostery Regulate Enzyme Function.
Holliday MJ, Camilloni C, Armstrong GS, Vendruscolo M, Eisenmesser EZ. Holliday MJ, et al. Structure. 2017 Feb 7;25(2):276-286. doi: 10.1016/j.str.2016.12.003. Epub 2017 Jan 12. Structure. 2017. PMID: 28089447 Free PMC article.
Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism.
Camilloni C, Sahakyan AB, Holliday MJ, Isern NG, Zhang F, Eisenmesser EZ, Vendruscolo M. Camilloni C, et al. Among authors: holliday mj. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10203-8. doi: 10.1073/pnas.1404220111. Epub 2014 Jun 30. Proc Natl Acad Sci U S A. 2014. PMID: 24982184 Free PMC article.
40 results