Hu X - Search Results

1

Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.

Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Krueger AB, et al. Among authors: hu x. J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22. J Biol Chem. 2014. PMID: 24755226 Free PMC article.

2

Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease.

Geng H, Whiteley G, Ribbens J, Zheng W, Southall N, Hu X, Marugan JJ, Ferrer M, Maegawa GH. Geng H, et al. Among authors: hu x. PLoS One. 2011;6(12):e29504. doi: 10.1371/journal.pone.0029504. Epub 2011 Dec 21. PLoS One. 2011. PMID: 22216298 Free PMC article.

3

Discovery of a novel noniminosugar acid α glucosidase chaperone series.

Xiao J, Westbroek W, Motabar O, Lea WA, Hu X, Velayati A, Zheng W, Southall N, Gustafson AM, Goldin E, Sidransky E, Liu K, Simeonov A, Tamargo RJ, Ribes A, Matalonga L, Ferrer M, Marugan JJ. Xiao J, et al. Among authors: hu x. J Med Chem. 2012 Sep 13;55(17):7546-59. doi: 10.1021/jm3005543. Epub 2012 Aug 17. J Med Chem. 2012. PMID: 22834902 Free PMC article.

4

A high-throughput screening assay using Krabbe disease patient cells.

Ribbens J, Whiteley G, Furuya H, Southall N, Hu X, Marugan J, Ferrer M, Maegawa GH. Ribbens J, et al. Among authors: hu x. Anal Biochem. 2013 Mar 1;434(1):15-25. doi: 10.1016/j.ab.2012.10.034. Epub 2012 Nov 5. Anal Biochem. 2013. PMID: 23138179 Free PMC article.

5

Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay.

Chen CZ, Southall N, Xiao J, Marugan JJ, Ferrer M, Hu X, Jones RE, Feng S, Agoulnik IU, Zheng W, Agoulnik AI. Chen CZ, et al. Among authors: hu x. J Biomol Screen. 2013 Jul;18(6):670-7. doi: 10.1177/1087057112469406. Epub 2012 Dec 4. J Biomol Screen. 2013. PMID: 23212924 Free PMC article.

6

Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches.

Hu X, Vujanac M, Southall N, Stebbins CE. Hu X, et al. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1056-62. doi: 10.1016/j.bmcl.2012.12.018. Epub 2012 Dec 20. Bioorg Med Chem Lett. 2013. PMID: 23294700 Free PMC article.

7

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

Xiao J, Huang Z, Chen CZ, Agoulnik IU, Southall N, Hu X, Jones RE, Ferrer M, Zheng W, Agoulnik AI, Marugan JJ. Xiao J, et al. Among authors: hu x. Nat Commun. 2013;4:1953. doi: 10.1038/ncomms2953. Nat Commun. 2013. PMID: 23764525 Free PMC article.

8

Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion.

Srinivasan P, Yasgar A, Luci DK, Beatty WL, Hu X, Andersen J, Narum DL, Moch JK, Sun H, Haynes JD, Maloney DJ, Jadhav A, Simeonov A, Miller LH. Srinivasan P, et al. Among authors: hu x. Nat Commun. 2013;4:2261. doi: 10.1038/ncomms3261. Nat Commun. 2013. PMID: 23907321 Free PMC article.

9

Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds.

Hu Z, Lan KH, He S, Swaroop M, Hu X, Southall N, Zheng W, Liang TJ. Hu Z, et al. Among authors: hu x. Antimicrob Agents Chemother. 2014;58(2):995-1004. doi: 10.1128/AAC.02094-13. Epub 2013 Nov 25. Antimicrob Agents Chemother. 2014. PMID: 24277038 Free PMC article.

10

Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.

Duveau DY, Yasgar A, Wang Y, Hu X, Kouznetsova J, Brimacombe KR, Jadhav A, Simeonov A, Thomas CJ, Maloney DJ. Duveau DY, et al. Among authors: hu x. Bioorg Med Chem Lett. 2014 Jan 15;24(2):630-5. doi: 10.1016/j.bmcl.2013.11.081. Epub 2013 Dec 4. Bioorg Med Chem Lett. 2014. PMID: 24360556 Free PMC article.

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