Johnson AP - Search Results

1

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.

Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, Moroni A. Lolicato M, et al. Among authors: johnson ap. Nat Chem Biol. 2014 Jun;10(6):457-62. doi: 10.1038/nchembio.1521. Epub 2014 Apr 28. Nat Chem Biol. 2014. PMID: 24776929 Free article.

2

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT.

Simmons KJ, Gotfryd K, Billesbølle CB, Loland CJ, Gether U, Fishwick CW, Johnson AP. Simmons KJ, et al. Among authors: johnson ap. Mol Membr Biol. 2013 Mar;30(2):184-94. doi: 10.3109/09687688.2012.710341. Epub 2012 Aug 21. Mol Membr Biol. 2013. PMID: 22908980 Free article.

3

An in silico structure-based approach to anti-infective drug discovery.

Cunningham F, McPhillie MJ, Johnson AP, Fishwick CW. Cunningham F, et al. Among authors: johnson ap. Parasitology. 2014 Jan;141(1):17-27. doi: 10.1017/S0031182013000693. Epub 2013 Jun 17. Parasitology. 2014. PMID: 23768800 Review.

4

A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli.

Besong GE, Bostock JM, Stubbings W, Chopra I, Roper DI, Lloyd AJ, Fishwick CW, Johnson AP. Besong GE, et al. Among authors: johnson ap. Angew Chem Int Ed Engl. 2005 Oct 7;44(39):6403-6. doi: 10.1002/anie.200501662. Angew Chem Int Ed Engl. 2005. PMID: 16158456 No abstract available.

5

A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH.

Cowen D, Bedingfield P, McConkey GA, Fishwick CW, Johnson AP. Cowen D, et al. Among authors: johnson ap. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1284-7. doi: 10.1016/j.bmcl.2009.11.079. Epub 2009 Nov 27. Bioorg Med Chem Lett. 2010. PMID: 20034791

6

Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.

Wacker SJ, Jurkowski W, Simmons KJ, Fishwick CW, Johnson AP, Madge D, Lindahl E, Rolland JF, de Groot BL. Wacker SJ, et al. Among authors: johnson ap. ChemMedChem. 2012 Oct;7(10):1775-83. doi: 10.1002/cmdc.201100600. Epub 2012 Mar 30. ChemMedChem. 2012. PMID: 22473914 Free PMC article.

7

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening.

Yi Mok N, Chadwick J, Kellett KA, Hooper NM, Johnson AP, Fishwick CW. Yi Mok N, et al. Among authors: johnson ap. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6770-4. doi: 10.1016/j.bmcl.2009.09.103. Epub 2009 Oct 2. Bioorg Med Chem Lett. 2009. PMID: 19854048

8

A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis.

Kankanala J, Latham AM, Johnson AP, Homer-Vanniasinkam S, Fishwick CW, Ponnambalam S. Kankanala J, et al. Among authors: johnson ap. Br J Pharmacol. 2012 May;166(2):737-48. doi: 10.1111/j.1476-5381.2011.01801.x. Br J Pharmacol. 2012. PMID: 22141913 Free PMC article.

9

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.

Davies M, Heikkilä T, McConkey GA, Fishwick CW, Parsons MR, Johnson AP. Davies M, et al. Among authors: johnson ap. J Med Chem. 2009 May 14;52(9):2683-93. doi: 10.1021/jm800963t. J Med Chem. 2009. PMID: 19351152

10

Molecular mechanism of ligand recognition by membrane transport protein, Mhp1.

Simmons KJ, Jackson SM, Brueckner F, Patching SG, Beckstein O, Ivanova E, Geng T, Weyand S, Drew D, Lanigan J, Sharples DJ, Sansom MS, Iwata S, Fishwick CW, Johnson AP, Cameron AD, Henderson PJ. Simmons KJ, et al. Among authors: johnson ap. EMBO J. 2014 Aug 18;33(16):1831-44. doi: 10.15252/embj.201387557. Epub 2014 Jun 21. EMBO J. 2014. PMID: 24952894 Free PMC article.

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