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Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
Antoniades C, Cunnington C, Antonopoulos A, Neville M, Margaritis M, Demosthenous M, Bendall J, Hale A, Cerrato R, Tousoulis D, Bakogiannis C, Marinou K, Toutouza M, Vlachopoulos C, Leeson P, Stefanadis C, Karpe F, Channon KM. Antoniades C, et al. Circulation. 2011 Oct 25;124(17):1860-70. doi: 10.1161/CIRCULATIONAHA.111.029272. Epub 2011 Oct 3. Circulation. 2011. PMID: 21969008 Free PMC article. Clinical Trial.
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Bailey JD, Diotallevi M, Nicol T, McNeill E, Shaw A, Chuaiphichai S, Hale A, Starr A, Nandi M, Stylianou E, McShane H, Davis S, Fischer R, Kessler BM, McCullagh J, Channon KM, Crabtree MJ. Bailey JD, et al. Cell Rep. 2019 Jul 2;28(1):218-230.e7. doi: 10.1016/j.celrep.2019.06.018. Cell Rep. 2019. PMID: 31269442 Free PMC article.
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
Crabtree MJ, Tatham AL, Al-Wakeel Y, Warrick N, Hale AB, Cai S, Channon KM, Alp NJ. Crabtree MJ, et al. Among authors: hale ab. J Biol Chem. 2009 Jan 9;284(2):1136-44. doi: 10.1074/jbc.M805403200. Epub 2008 Nov 14. J Biol Chem. 2009. PMID: 19011239 Free article.
46 results