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Page 1
Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03:04 and modulate primary natural killer cell function.
van Teijlingen NH, Hölzemer A, Körner C, García-Beltrán WF, Schafer JL, Fadda L, Suscovich TJ, Brander C, Carrington M, Evans DT, van Baarle D, Altfeld M. van Teijlingen NH, et al. Among authors: holzemer a. AIDS. 2014 Jun 19;28(10):1399-408. doi: 10.1097/QAD.0000000000000284. AIDS. 2014. PMID: 24785948 Free PMC article.
Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.
Hölzemer A, Thobakgale CF, Jimenez Cruz CA, Garcia-Beltran WF, Carlson JM, van Teijlingen NH, Mann JK, Jaggernath M, Kang SG, Körner C, Chung AW, Schafer JL, Evans DT, Alter G, Walker BD, Goulder PJ, Carrington M, Hartmann P, Pertel T, Zhou R, Ndung'u T, Altfeld M. Hölzemer A, et al. PLoS Med. 2015 Nov 17;12(11):e1001900; discussion e1001900. doi: 10.1371/journal.pmed.1001900. eCollection 2015 Nov. PLoS Med. 2015. PMID: 26575988 Free PMC article.
Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.
Garcia-Beltran WF, Hölzemer A, Martrus G, Chung AW, Pacheco Y, Simoneau CR, Rucevic M, Lamothe-Molina PA, Pertel T, Kim TE, Dugan H, Alter G, Dechanet-Merville J, Jost S, Carrington M, Altfeld M. Garcia-Beltran WF, et al. Among authors: holzemer a. Nat Immunol. 2016 Sep;17(9):1067-74. doi: 10.1038/ni.3513. Epub 2016 Jul 25. Nat Immunol. 2016. PMID: 27455421 Free PMC article.
HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells.
Körner C, Simoneau CR, Schommers P, Granoff M, Ziegler M, Hölzemer A, Lunemann S, Chukwukelu J, Corleis B, Naranbhai V, Kwon DS, Scully EP, Jost S, Kirchhoff F, Carrington M, Altfeld M. Körner C, et al. Among authors: holzemer a. Cell Host Microbe. 2017 Jul 12;22(1):111-119.e4. doi: 10.1016/j.chom.2017.06.008. Cell Host Microbe. 2017. PMID: 28704647 Free PMC article.
Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture.
Lunemann S, Schöbel A, Kah J, Fittje P, Hölzemer A, Langeneckert AE, Hess LU, Poch T, Martrus G, Garcia-Beltran WF, Körner C, Ziegler AE, Richert L, Oldhafer KJ, Schulze Zur Wiesch J, Schramm C, Dandri M, Herker E, Altfeld M. Lunemann S, et al. Among authors: holzemer a. Gastroenterology. 2018 Nov;155(5):1366-1371.e3. doi: 10.1053/j.gastro.2018.07.019. Epub 2018 Jul 19. Gastroenterology. 2018. PMID: 30031767
A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44.
Niehrs A, Garcia-Beltran WF, Norman PJ, Watson GM, Hölzemer A, Chapel A, Richert L, Pommerening-Röser A, Körner C, Ozawa M, Martrus G, Rossjohn J, Lee JH, Berry R, Carrington M, Altfeld M. Niehrs A, et al. Among authors: holzemer a. Nat Immunol. 2019 Sep;20(9):1129-1137. doi: 10.1038/s41590-019-0448-4. Epub 2019 Jul 29. Nat Immunol. 2019. PMID: 31358998 Free PMC article.
Primary HIV-1 Strains Use Nef To Downmodulate HLA-E Surface Expression.
van Stigt Thans T, Akko JI, Niehrs A, Garcia-Beltran WF, Richert L, Stürzel CM, Ford CT, Li H, Ochsenbauer C, Kappes JC, Hahn BH, Kirchhoff F, Martrus G, Sauter D, Altfeld M, Hölzemer A. van Stigt Thans T, et al. Among authors: holzemer a. J Virol. 2019 Sep 30;93(20):e00719-19. doi: 10.1128/JVI.00719-19. Print 2019 Oct 15. J Virol. 2019. PMID: 31375574 Free PMC article.
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