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Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes.
Paneni F, Costantino S, Castello L, Battista R, Capretti G, Chiandotto S, D'Amario D, Scavone G, Villano A, Rustighi A, Crea F, Pitocco D, Lanza G, Volpe M, Del Sal G, Lüscher TF, Cosentino F. Paneni F, et al. Among authors: del sal g. Eur Heart J. 2015 Apr 1;36(13):817-28. doi: 10.1093/eurheartj/ehu179. Epub 2014 May 5. Eur Heart J. 2015. PMID: 24801072 Free article.
Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RARalpha and PML-RARalpha.
Gianni' M, Boldetti A, Guarnaccia V, Rambaldi A, Parrella E, Raska I Jr, Rochette-Egly C, Del Sal G, Rustighi A, Terao M, Garattini E. Gianni' M, et al. Among authors: del sal g. Cancer Res. 2009 Feb 1;69(3):1016-26. doi: 10.1158/0008-5472.CAN-08-2603. Epub 2009 Jan 20. Cancer Res. 2009. PMID: 19155306
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
Girardini JE, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, Capaci V, Jordan L, Quinlan P, Thompson A, Mano M, Rosato A, Crook T, Scanziani E, Means AR, Lozano G, Schneider C, Del Sal G. Girardini JE, et al. Among authors: del sal g. Cancer Cell. 2011 Jul 12;20(1):79-91. doi: 10.1016/j.ccr.2011.06.004. Cancer Cell. 2011. PMID: 21741598 Free article.
The prolyl-isomerase Pin1 activates the mitochondrial death program of p53.
Sorrentino G, Mioni M, Giorgi C, Ruggeri N, Pinton P, Moll U, Mantovani F, Del Sal G. Sorrentino G, et al. Among authors: del sal g. Cell Death Differ. 2013 Feb;20(2):198-208. doi: 10.1038/cdd.2012.112. Epub 2012 Aug 31. Cell Death Differ. 2013. PMID: 22935610 Free PMC article.
156 results