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A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.
Kallop DY, Meilandt WJ, Gogineni A, Easley-Neal C, Wu T, Jubb AM, Yaylaoglu M, Shamloo M, Tessier-Lavigne M, Scearce-Levie K, Weimer RM. Kallop DY, et al. Among authors: easley neal c. J Neurosci. 2014 May 7;34(19):6425-37. doi: 10.1523/JNEUROSCI.4963-13.2014. J Neurosci. 2014. PMID: 24806669 Free PMC article.
Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.
Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M. Olsen O, et al. Among authors: easley neal c. J Neurosci. 2014 May 7;34(19):6438-47. doi: 10.1523/JNEUROSCI.3522-13.2014. J Neurosci. 2014. PMID: 24806670 Free PMC article.