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Family of prokaryote cyclic nucleotide-modulated ion channels.
Brams M, Kusch J, Spurny R, Benndorf K, Ulens C. Brams M, et al. Among authors: spurny r. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7855-60. doi: 10.1073/pnas.1401917111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821777 Free PMC article.
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.
Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C. Spurny R, et al. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34. doi: 10.1073/pnas.1208208109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035248 Free PMC article.
Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.
Nys M, Wijckmans E, Farinha A, Yoluk Ö, Andersson M, Brams M, Spurny R, Peigneur S, Tytgat J, Lindahl E, Ulens C. Nys M, et al. Among authors: spurny r. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6696-E6703. doi: 10.1073/pnas.1603101113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791038 Free PMC article.
A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, Baenziger JE, Ulens C. Hénault CM, et al. Among authors: spurny r. Nat Chem Biol. 2019 Dec;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4. Epub 2019 Oct 7. Nat Chem Biol. 2019. PMID: 31591563 Free PMC article.
17 results