Girotti MR - Search Results

1

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors.

Marusiak AA, Edwards ZC, Hugo W, Trotter EW, Girotti MR, Stephenson NL, Kong X, Gartside MG, Fawdar S, Hudson A, Breitwieser W, Hayward NK, Marais R, Lo RS, Brognard J. Marusiak AA, et al. Among authors: girotti mr. Nat Commun. 2014 May 22;5:3901. doi: 10.1038/ncomms4901. Nat Commun. 2014. PMID: 24849047 Free PMC article.

2

Deja Vu: EGF receptors drive resistance to BRAF inhibitors.

Girotti MR, Marais R. Girotti MR, et al. Cancer Discov. 2013 May;3(5):487-90. doi: 10.1158/2159-8290.CD-13-0131. Cancer Discov. 2013. PMID: 23658295 Free PMC article.

3

Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53.

Viros A, Sanchez-Laorden B, Pedersen M, Furney SJ, Rae J, Hogan K, Ejiama S, Girotti MR, Cook M, Dhomen N, Marais R. Viros A, et al. Among authors: girotti mr. Nature. 2014 Jul 24;511(7510):478-482. doi: 10.1038/nature13298. Epub 2014 Jun 11. Nature. 2014. PMID: 24919155 Free PMC article.

4

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.

Girotti MR, Lopes F, Preece N, Niculescu-Duvaz D, Zambon A, Davies L, Whittaker S, Saturno G, Viros A, Pedersen M, Suijkerbuijk BM, Menard D, McLeary R, Johnson L, Fish L, Ejiama S, Sanchez-Laorden B, Hohloch J, Carragher N, Macleod K, Ashton G, Marusiak AA, Fusi A, Brognard J, Frame M, Lorigan P, Marais R, Springer C. Girotti MR, et al. Cancer Cell. 2015 Jan 12;27(1):85-96. doi: 10.1016/j.ccell.2014.11.006. Epub 2014 Dec 11. Cancer Cell. 2015. PMID: 25500121 Free PMC article.

5

So You Can Teach Old Fibroblasts New Tricks.

Virós A, Girotti MR, Marais R. Virós A, et al. Among authors: girotti mr. Cancer Discov. 2016 Jun;6(6):581-3. doi: 10.1158/2159-8290.CD-16-0503. Cancer Discov. 2016. PMID: 27261482 Free PMC article.

6

BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling.

Sanchez-Laorden B, Viros A, Girotti MR, Pedersen M, Saturno G, Zambon A, Niculescu-Duvaz D, Turajlic S, Hayes A, Gore M, Larkin J, Lorigan P, Cook M, Springer C, Marais R. Sanchez-Laorden B, et al. Among authors: girotti mr. Sci Signal. 2014 Mar 25;7(318):ra30. doi: 10.1126/scisignal.2004815. Sci Signal. 2014. PMID: 24667377

7

No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patients.

Girotti MR, Saturno G, Lorigan P, Marais R. Girotti MR, et al. Mol Oncol. 2014 Sep 12;8(6):1140-58. doi: 10.1016/j.molonc.2014.07.027. Epub 2014 Aug 15. Mol Oncol. 2014. PMID: 25178978 Free PMC article. Review.

8

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells.

Baenke F, Chaneton B, Smith M, Van Den Broek N, Hogan K, Tang H, Viros A, Martin M, Galbraith L, Girotti MR, Dhomen N, Gottlieb E, Marais R. Baenke F, et al. Among authors: girotti mr. Mol Oncol. 2016 Jan;10(1):73-84. doi: 10.1016/j.molonc.2015.08.003. Epub 2015 Aug 20. Mol Oncol. 2016. PMID: 26365896 Free PMC article.

9

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.

Smith MP, Brunton H, Rowling EJ, Ferguson J, Arozarena I, Miskolczi Z, Lee JL, Girotti MR, Marais R, Levesque MP, Dummer R, Frederick DT, Flaherty KT, Cooper ZA, Wargo JA, Wellbrock C. Smith MP, et al. Among authors: girotti mr. Cancer Cell. 2016 Mar 14;29(3):270-284. doi: 10.1016/j.ccell.2016.02.003. Cancer Cell. 2016. PMID: 26977879 Free PMC article.

10

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling.

Hirata E, Girotti MR, Viros A, Hooper S, Spencer-Dene B, Matsuda M, Larkin J, Marais R, Sahai E. Hirata E, et al. Among authors: girotti mr. Cancer Cell. 2015 Apr 13;27(4):574-88. doi: 10.1016/j.ccell.2015.03.008. Cancer Cell. 2015. PMID: 25873177 Free PMC article.

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