O'Neill PM - Search Results

1

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.

Walsh J, Jenkins RE, Wong M, Olayanju A, Powell H, Copple I, O'Neill PM, Goldring CE, Kitteringham NR, Park BK. Walsh J, et al. J Proteomics. 2014 Aug 28;108(100):171-87. doi: 10.1016/j.jprot.2014.05.007. Epub 2014 May 21. J Proteomics. 2014. PMID: 24859727 Free PMC article.

2

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.

Wong MH, Bryan HK, Copple IM, Jenkins RE, Chiu PH, Bibby J, Berry NG, Kitteringham NR, Goldring CE, O'Neill PM, Park BK. Wong MH, et al. J Med Chem. 2016 Mar 24;59(6):2396-409. doi: 10.1021/acs.jmedchem.5b01292. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26908173 Free article.

3

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney.

Shelton LM, Lister A, Walsh J, Jenkins RE, Wong MH, Rowe C, Ricci E, Ressel L, Fang Y, Demougin P, Vukojevic V, O'Neill PM, Goldring CE, Kitteringham NR, Park BK, Odermatt A, Copple IM. Shelton LM, et al. Kidney Int. 2015 Dec;88(6):1261-1273. doi: 10.1038/ki.2015.286. Epub 2015 Sep 30. Kidney Int. 2015. PMID: 26422507 Free PMC article.

4

The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.

Mercer AE, Copple IM, Maggs JL, O'Neill PM, Park BK. Mercer AE, et al. J Biol Chem. 2011 Jan 14;286(2):987-96. doi: 10.1074/jbc.M110.144188. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21059641 Free PMC article.

5

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.

Copple IM, Mercer AE, Firman J, Donegan G, Herpers B, Wong MH, Chadwick J, Bringela AD, Cristiano ML, van de Water B, Ward SA, O'Neill PM, Park BK. Copple IM, et al. Mol Med. 2012 Sep 25;18(1):1045-55. doi: 10.2119/molmed.2012.00154. Mol Med. 2012. PMID: 22669474 Free PMC article.

6

Oxidative bioactivation of abacavir in subcellular fractions of human antigen presenting cells.

Bell CC, Santoyo Castelazo A, Yang EL, Maggs JL, Jenkins RE, Tugwood J, O'Neill PM, Naisbitt DJ, Park BK. Bell CC, et al. Chem Res Toxicol. 2013 Jul 15;26(7):1064-72. doi: 10.1021/tx400041v. Epub 2013 Jun 12. Chem Res Toxicol. 2013. PMID: 23697900

7

Metabolism of fluorine-containing drugs.

Park BK, Kitteringham NR, O'Neill PM. Park BK, et al. Annu Rev Pharmacol Toxicol. 2001;41:443-70. doi: 10.1146/annurev.pharmtox.41.1.443. Annu Rev Pharmacol Toxicol. 2001. PMID: 11264465 Review.

8

Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds.

Mercer AE, Maggs JL, Sun XM, Cohen GM, Chadwick J, O'Neill PM, Park BK. Mercer AE, et al. J Biol Chem. 2007 Mar 30;282(13):9372-9382. doi: 10.1074/jbc.M610375200. Epub 2007 Jan 16. J Biol Chem. 2007. PMID: 17227762 Free article.

9

Effect of disposition of mannich antimalarial agents on their pharmacology and toxicology.

Ruscoe JE, Tingle MD, O'Neill PM, Ward SA, Park BK. Ruscoe JE, et al. Antimicrob Agents Chemother. 1998 Sep;42(9):2410-6. doi: 10.1128/AAC.42.9.2410. Antimicrob Agents Chemother. 1998. PMID: 9736572 Free PMC article.

10

Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.

Elliott EC, Maggs JL, Park BK, O'Neill PM, Stachulski AV. Elliott EC, et al. Org Biomol Chem. 2013 Dec 28;11(48):8426-34. doi: 10.1039/c3ob41252k. Epub 2013 Nov 6. Org Biomol Chem. 2013. PMID: 24193242

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