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The novel antioxidant, AC3056 (2,6-di-t-butyl-4-((dimethyl-4-methoxyphenylsilyl)methyloxy)phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men.
Angulo J, Peiró C, Cuevas P, Gabancho S, Fernández A, González-Corrochano R, La Fuente JM, Baron AD, Chen KS, de Tejada IS. Angulo J, et al. Among authors: cuevas p. J Sex Med. 2009 Feb;6(2):373-87. doi: 10.1111/j.1743-6109.2008.01088.x. Epub 2008 Nov 18. J Sex Med. 2009. PMID: 19040617
Ca2+ -activated K+ channel (KCa) stimulation improves relaxant capacity of PDE5 inhibitors in human penile arteries and recovers the reduced efficacy of PDE5 inhibition in diabetic erectile dysfunction.
González-Corrochano R, La Fuente J, Cuevas P, Fernández A, Chen M, Sáenz de Tejada I, Angulo J. González-Corrochano R, et al. Among authors: cuevas p. Br J Pharmacol. 2013 May;169(2):449-61. doi: 10.1111/bph.12143. Br J Pharmacol. 2013. PMID: 23441682 Free PMC article.
Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity.
Angulo J, Cuevas P, Fernández A, Allona A, Moncada I, Martín-Morales A, La Fuente JM, de Tejada IS. Angulo J, et al. Among authors: cuevas p. J Pharmacol Exp Ther. 2006 Nov;319(2):783-9. doi: 10.1124/jpet.106.108597. Epub 2006 Aug 3. J Pharmacol Exp Ther. 2006. PMID: 16888082
250 results