Wexler RR - Search Results

1

Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors.

Johnson JA, Xu N, Jeon Y, Finlay HJ, Kover A, Conder ML, Sun H, Li D, Levesque P, Hsueh MM, Harper TW, Wexler RR, Lloyd J. Johnson JA, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3018-22. doi: 10.1016/j.bmcl.2014.05.035. Epub 2014 May 20. Bioorg Med Chem Lett. 2014. PMID: 24881565

2

The de novo design and synthesis of cyclic urea inhibitors of factor Xa: initial SAR studies.

Galemmo RA Jr, Maduskuie TP, Dominguez C, Rossi KA, Knabb RM, Wexler RR, Stouten PF. Galemmo RA Jr, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2705-10. doi: 10.1016/s0960-894x(98)00471-5. Bioorg Med Chem Lett. 1998. PMID: 9873607

3

Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors.

Dominguez C, Duffy DE, Han Q, Alexander RS, Galemmo RA Jr, Park JM, Wong PC, Amparo EC, Knabb RM, Luettgen J, Wexler RR. Dominguez C, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 1999 Apr 5;9(7):925-30. doi: 10.1016/s0960-894x(99)00113-4. Bioorg Med Chem Lett. 1999. PMID: 10230612

4

Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.

Quan ML, Liauw AY, Ellis CD, Pruitt JR, Carini DJ, Bostrom LL, Huang PP, Harrison K, Knabb RM, Thoolen MJ, Wong PC, Wexler RR. Quan ML, et al. Among authors: wexler rr. J Med Chem. 1999 Jul 29;42(15):2752-9. doi: 10.1021/jm980405i. J Med Chem. 1999. PMID: 10425086

5

Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2.

Quan ML, Ellis CD, Liauw AY, Alexander RS, Knabb RM, Lam G, Wright MR, Wong PC, Wexler RR. Quan ML, et al. Among authors: wexler rr. J Med Chem. 1999 Jul 29;42(15):2760-73. doi: 10.1021/jm980406a. J Med Chem. 1999. PMID: 10425087

6

The de novo design and synthesis of cyclic urea inhibitors of factor Xa: optimization of the S4 ligand.

Galemmo RA Jr, Wells BL, Rossi KA, Alexander RS, Dominguez C, Maduskuie TP, Stouten PF, Wright MR, Aungst BJ, Wong PC, Knabb RM, Wexler RR. Galemmo RA Jr, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2000 Feb 7;10(3):301-4. doi: 10.1016/s0960-894x(99)00688-5. Bioorg Med Chem Lett. 2000. PMID: 10698459

7

Isoxazolines and isoxazoles as factor Xa inhibitors.

Pruitt JR, Pinto DJ, Estrella MJ, Bostrom LL, Knabb RM, Wong PC, Wright MR, Wexler RR. Pruitt JR, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2000 Apr 17;10(8):685-9. doi: 10.1016/s0960-894x(00)00097-4. Bioorg Med Chem Lett. 2000. PMID: 10782664

8

Synthesis and activity studies of conformationally restricted alpha-ketoamide factor Xa inhibitors.

Cacciola J, Fevig JM, Stouten PF, Alexander RS, Knabb RM, Wexler RR. Cacciola J, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1253-6. doi: 10.1016/s0960-894x(00)00215-8. Bioorg Med Chem Lett. 2000. PMID: 10866393

9

Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors.

Han Q, Dominguez C, Stouten PF, Park JM, Duffy DE, Galemmo RA Jr, Rossi KA, Alexander RS, Smallwood AM, Wong PC, Wright MM, Luettgen JM, Knabb RM, Wexler RR. Han Q, et al. Among authors: wexler rr. J Med Chem. 2000 Nov 16;43(23):4398-415. doi: 10.1021/jm000113t. J Med Chem. 2000. PMID: 11087565

10

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.

Fevig JM, Pinto DJ, Han Q, Quan ML, Pruitt JR, Jacobson IC, Galemmo RA Jr, Wang S, Orwat MJ, Bostrom LL, Knabb RM, Wong PC, Lam PYS, Wexler RR. Fevig JM, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2001 Mar 12;11(5):641-5. doi: 10.1016/s0960-894x(01)00029-4. Bioorg Med Chem Lett. 2001. PMID: 11266160

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