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Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pylori.
Hoffman PS, Bruce AM, Olekhnovich I, Warren CA, Burgess SL, Hontecillas R, Viladomiu M, Bassaganya-Riera J, Guerrant RL, Macdonald TL. Hoffman PS, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4703-12. doi: 10.1128/AAC.03112-14. Epub 2014 Jun 2. Antimicrob Agents Chemother. 2014. PMID: 24890599 Free PMC article.
Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model.
Warren CA, van Opstal E, Ballard TE, Kennedy A, Wang X, Riggins M, Olekhnovich I, Warthan M, Kolling GL, Guerrant RL, Macdonald TL, Hoffman PS. Warren CA, et al. Among authors: hoffman ps. Antimicrob Agents Chemother. 2012 Aug;56(8):4103-11. doi: 10.1128/AAC.00360-12. Epub 2012 May 14. Antimicrob Agents Chemother. 2012. PMID: 22585229 Free PMC article.
Vancomycin treatment's association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice.
Warren CA, van Opstal EJ, Riggins MS, Li Y, Moore JH, Kolling GL, Guerrant RL, Hoffman PS. Warren CA, et al. Among authors: hoffman ps. Antimicrob Agents Chemother. 2013 Feb;57(2):689-96. doi: 10.1128/AAC.00877-12. Epub 2012 Nov 12. Antimicrob Agents Chemother. 2013. PMID: 23147742 Free PMC article.
Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate-Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilonproteobacteria.
Kennedy AJ, Bruce AM, Gineste C, Ballard TE, Olekhnovich IN, Macdonald TL, Hoffman PS. Kennedy AJ, et al. Among authors: hoffman ps. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3980-7. doi: 10.1128/AAC.00670-16. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27090174 Free PMC article.
114 results