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Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine.
Dash R, Richards JE, Su ZZ, Bhutia SK, Azab B, Rahmani M, Dasmahapatra G, Yacoub A, Dent P, Dmitriev IP, Curiel DT, Grant S, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Dash R, et al. Among authors: pellecchia m. Cancer Res. 2010 Jun 15;70(12):5034-45. doi: 10.1158/0008-5472.CAN-10-0563. Epub 2010 May 25. Cancer Res. 2010. PMID: 20501829 Free PMC article.
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.
Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Dash R, et al. Among authors: pellecchia m. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8785-90. doi: 10.1073/pnas.1100769108. Epub 2011 May 9. Proc Natl Acad Sci U S A. 2011. PMID: 21555592 Free PMC article.
Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells.
Azab B, Dash R, Das SK, Bhutia SK, Shen XN, Quinn BA, Sarkar S, Wang XY, Hedvat M, Dmitriev IP, Curiel DT, Grant S, Dent P, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Azab B, et al. Among authors: pellecchia m. J Cell Physiol. 2012 May;227(5):2145-53. doi: 10.1002/jcp.22947. J Cell Physiol. 2012. PMID: 21780116 Free PMC article.
Raf kinase inhibitor RKIP inhibits MDA-9/syntenin-mediated metastasis in melanoma.
Das SK, Bhutia SK, Sokhi UK, Azab B, Su ZZ, Boukerche H, Anwar T, Moen EL, Chatterjee D, Pellecchia M, Sarkar D, Fisher PB. Das SK, et al. Among authors: pellecchia m. Cancer Res. 2012 Dec 1;72(23):6217-26. doi: 10.1158/0008-5472.CAN-12-0402. Epub 2012 Oct 11. Cancer Res. 2012. PMID: 23066033 Free PMC article.
Targeting the Bcl-2 family for cancer therapy.
Thomas S, Quinn BA, Das SK, Dash R, Emdad L, Dasgupta S, Wang XY, Dent P, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Thomas S, et al. Among authors: pellecchia m. Expert Opin Ther Targets. 2013 Jan;17(1):61-75. doi: 10.1517/14728222.2013.733001. Epub 2012 Nov 22. Expert Opin Ther Targets. 2013. PMID: 23173842 Free PMC article. Review.
MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.
Das SK, Bhutia SK, Azab B, Kegelman TP, Peachy L, Santhekadur PK, Dasgupta S, Dash R, Dent P, Grant S, Emdad L, Pellecchia M, Sarkar D, Fisher PB. Das SK, et al. Among authors: pellecchia m. Cancer Res. 2013 Jan 15;73(2):844-54. doi: 10.1158/0008-5472.CAN-12-1681. Epub 2012 Dec 10. Cancer Res. 2013. PMID: 23233738 Free PMC article.
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