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911 results

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Page 1
Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors.
Lazerwith SE, Bahador G, Canales E, Cheng G, Chong L, Clarke MO, Doerffler E, Eisenberg EJ, Hayes J, Lu B, Liu Q, Matles M, Mertzman M, Mitchell ML, Morganelli P, Murray BP, Robinson M, Strickley RG, Tessler M, Tirunagari N, Wang J, Wang Y, Zhang JR, Zheng X, Zhong W, Watkins WJ. Lazerwith SE, et al. Among authors: chong l. ACS Med Chem Lett. 2011 Aug 8;2(10):715-9. doi: 10.1021/ml200163b. eCollection 2011 Oct 13. ACS Med Chem Lett. 2011. PMID: 24900257 Free PMC article.
HCV NS5B polymerase inhibitors.
Watkins WJ, Ray AS, Chong LS. Watkins WJ, et al. Curr Opin Drug Discov Devel. 2010 Jul;13(4):441-65. Curr Opin Drug Discov Devel. 2010. PMID: 20597029 Review.
Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.
Watkins WJ, Chen JM, Cho A, Chong L, Collins N, Fardis M, Huang W, Hung M, Kirschberg T, Lee WA, Liu X, Thomas W, Xu J, Zeynalzadegan A, Zhang J. Watkins WJ, et al. Among authors: chong l. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3479-83. doi: 10.1016/j.bmcl.2006.03.097. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621550
Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection.
Lazerwith SE, Lew W, Zhang J, Morganelli P, Liu Q, Canales E, Clarke MO, Doerffler E, Byun D, Mertzman M, Ye H, Chong L, Xu L, Appleby T, Chen X, Fenaux M, Hashash A, Leavitt SA, Mabery E, Matles M, Mwangi JW, Tian Y, Lee YJ, Zhang J, Zhu C, Murray BP, Watkins WJ. Lazerwith SE, et al. Among authors: chong l. J Med Chem. 2014 Mar 13;57(5):1893-901. doi: 10.1021/jm401420j. Epub 2013 Nov 6. J Med Chem. 2014. PMID: 24144213
Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization.
Watkins WJ, Chong L, Cho A, Hilgenkamp R, Ludwikow M, Garizi N, Iqbal N, Barnard J, Singh R, Madsen D, Lolans K, Lomovskaya O, Oza U, Kumaraswamy P, Blecken A, Bai S, Loury DJ, Griffith DC, Dudley MN. Watkins WJ, et al. Among authors: chong l. Bioorg Med Chem Lett. 2007 May 15;17(10):2802-6. doi: 10.1016/j.bmcl.2007.02.047. Epub 2007 Feb 27. Bioorg Med Chem Lett. 2007. PMID: 17350259
Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives.
Watkins WJ, Lemoine RC, Chong L, Cho A, Renau TE, Kuo B, Wong V, Ludwikow M, Garizi N, Iqbal N, Barnard J, Jankowska R, Singh R, Madsen D, Lolans K, Lomovskaya O, Oza U, Dudley MN. Watkins WJ, et al. Among authors: chong l. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5133-7. doi: 10.1016/j.bmcl.2004.07.071. Bioorg Med Chem Lett. 2004. PMID: 15380214
GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma.
Reiser H, Wang J, Chong L, Watkins WJ, Ray AS, Shibata R, Birkus G, Cihlar T, Wu S, Li B, Liu X, Henne IN, Wolfgang GH, Desai M, Rhodes GR, Fridland A, Lee WA, Plunkett W, Vail D, Thamm DH, Jeraj R, Tumas DB. Reiser H, et al. Among authors: chong l. Clin Cancer Res. 2008 May 1;14(9):2824-32. doi: 10.1158/1078-0432.CCR-07-2061. Clin Cancer Res. 2008. PMID: 18451250
The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.
Groutas WC, Chong LS, Venkataraman R, Epp JB, Kuang R, Houser-Archield N, Hoidal JR. Groutas WC, et al. Among authors: chong ls. Bioorg Med Chem. 1995 Feb;3(2):187-93. doi: 10.1016/0968-0896(95)00013-7. Bioorg Med Chem. 1995. PMID: 7796053
911 results