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Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.
Skerlj RT, Bastos CM, Booker ML, Kramer ML, Barker RH Jr, Celatka CA, O'Shea TJ, Munoz B, Sidhu AB, Cortese JF, Wittlin S, Papastogiannidis P, Angulo-Barturen I, Jimenez-Diaz MB, Sybertz E. Skerlj RT, et al. Among authors: sybertz e. ACS Med Chem Lett. 2011 Jul 11;2(9):708-13. doi: 10.1021/ml200143c. eCollection 2011 Sep 8. ACS Med Chem Lett. 2011. PMID: 24900364 Free PMC article.
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Booker ML, et al. Among authors: sybertz e. J Biol Chem. 2010 Oct 22;285(43):33054-33064. doi: 10.1074/jbc.M110.162081. Epub 2010 Aug 11. J Biol Chem. 2010. PMID: 20702404 Free PMC article.
Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
Barker RH Jr, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E. Barker RH Jr, et al. Among authors: sybertz e. Antimicrob Agents Chemother. 2011 Jun;55(6):2612-22. doi: 10.1128/AAC.01714-10. Epub 2011 Mar 21. Antimicrob Agents Chemother. 2011. PMID: 21422215 Free PMC article.
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.
Barker RH Jr, Liu H, Hirth B, Celatka CA, Fitzpatrick R, Xiang Y, Willert EK, Phillips MA, Kaiser M, Bacchi CJ, Rodriguez A, Yarlett N, Klinger JD, Sybertz E. Barker RH Jr, et al. Among authors: sybertz e. Antimicrob Agents Chemother. 2009 May;53(5):2052-8. doi: 10.1128/AAC.01674-08. Epub 2009 Mar 16. Antimicrob Agents Chemother. 2009. PMID: 19289530 Free PMC article.
96 results