Rumpf T - Search Results

1

Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.

Maurer B, Rumpf T, Scharfe M, Stolfa DA, Schmitt ML, He W, Verdin E, Sippl W, Jung M. Maurer B, et al. Among authors: rumpf t. ACS Med Chem Lett. 2012 Oct 6;3(12):1050-3. doi: 10.1021/ml3002709. eCollection 2012 Dec 13. ACS Med Chem Lett. 2012. PMID: 24900427 Free PMC article.

2

Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).

Huber K, Schemies J, Uciechowska U, Wagner JM, Rumpf T, Lewrick F, Süss R, Sippl W, Jung M, Bracher F. Huber K, et al. Among authors: rumpf t. J Med Chem. 2010 Feb 11;53(3):1383-6. doi: 10.1021/jm901055u. J Med Chem. 2010. PMID: 20030343

3

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

Lawson M, Uciechowska U, Schemies J, Rumpf T, Jung M, Sippl W. Lawson M, et al. Among authors: rumpf t. Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):726-39. doi: 10.1016/j.bbagrm.2010.06.003. Epub 2010 Jun 23. Biochim Biophys Acta. 2010. PMID: 20601279 Review.

4

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.

Schiedel M, Rumpf T, Karaman B, Lehotzky A, Oláh J, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M. Schiedel M, et al. Among authors: rumpf t. J Med Chem. 2016 Feb 25;59(4):1599-612. doi: 10.1021/acs.jmedchem.5b01517. Epub 2016 Jan 7. J Med Chem. 2016. PMID: 26696402 Free article.

5

The Current State of NAD⁺ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.

Schiedel M, Robaa D, Rumpf T, Sippl W, Jung M. Schiedel M, et al. Among authors: rumpf t. Med Res Rev. 2018 Jan;38(1):147-200. doi: 10.1002/med.21436. Epub 2017 Jan 17. Med Res Rev. 2018. PMID: 28094444 Review.

6

Defined stereoisomers of 2″-amino NAD⁺ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase.

Zähringer S, Rumpf T, Melesina J, Lang AE, Aktories K, Sippl W, Jung M, Wagner GK. Zähringer S, et al. Among authors: rumpf t. Bioorg Med Chem. 2022 Aug 15;68:116875. doi: 10.1016/j.bmc.2022.116875. Epub 2022 Jun 3. Bioorg Med Chem. 2022. PMID: 35716588 Free article.

7

Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD).

Pesnot T, Kempter J, Schemies J, Pergolizzi G, Uciechowska U, Rumpf T, Sippl W, Jung M, Wagner GK. Pesnot T, et al. Among authors: rumpf t. J Med Chem. 2011 May 26;54(10):3492-9. doi: 10.1021/jm1013852. Epub 2011 Apr 29. J Med Chem. 2011. PMID: 21528845

8

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells.

Köhler J, Erlenkamp G, Eberlin A, Rumpf T, Slynko I, Metzger E, Schüle R, Sippl W, Jung M. Köhler J, et al. Among authors: rumpf t. PLoS One. 2012;7(4):e34973. doi: 10.1371/journal.pone.0034973. Epub 2012 Apr 20. PLoS One. 2012. PMID: 22532837 Free PMC article.

9

Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development.

Slynko I, Scharfe M, Rumpf T, Eib J, Metzger E, Schüle R, Jung M, Sippl W. Slynko I, et al. Among authors: rumpf t. J Chem Inf Model. 2014 Jan 27;54(1):138-50. doi: 10.1021/ci400628q. Epub 2014 Jan 8. J Chem Inf Model. 2014. PMID: 24377786

10

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M. Stolfa DA, et al. Among authors: rumpf t. J Mol Biol. 2014 Oct 9;426(20):3442-53. doi: 10.1016/j.jmb.2014.03.007. Epub 2014 Mar 20. J Mol Biol. 2014. PMID: 24657767 Free article.

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