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Page 1
Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.
Cho YS, Angove H, Brain C, Chen CH, Cheng H, Cheng R, Chopra R, Chung K, Congreve M, Dagostin C, Davis DJ, Feltell R, Giraldes J, Hiscock SD, Kim S, Kovats S, Lagu B, Lewry K, Loo A, Lu Y, Luzzio M, Maniara W, McMenamin R, Mortenson PN, Benning R, O'Reilly M, Rees DC, Shen J, Smith T, Wang Y, Williams G, Woolford AJ, Wrona W, Xu M, Yang F, Howard S. Cho YS, et al. Among authors: dagostin c. ACS Med Chem Lett. 2012 May 17;3(6):445-9. doi: 10.1021/ml200241a. eCollection 2012 Jun 14. ACS Med Chem Lett. 2012. PMID: 24900493 Free PMC article.
Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors.
Wang S, Beck R, Burd A, Blench T, Marlin F, Ayele T, Buxton S, Dagostin C, Malic M, Joshi R, Barry J, Sajad M, Cheung C, Shaikh S, Chahwala S, Chander C, Baumgartner C, Holthoff HP, Murray E, Blackney M, Giddings A. Wang S, et al. Among authors: dagostin c. J Med Chem. 2010 Feb 25;53(4):1473-82. doi: 10.1021/jm901476x. J Med Chem. 2010. PMID: 20121197
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.
Stockwell SR, Scott DE, Fischer G, Guarino E, Rooney TPC, Feng TS, Moschetti T, Srinivasan R, Alza E, Asteian A, Dagostin C, Alcaide A, Rocaboy M, Blaszczyk B, Higueruelo A, Wang X, Rossmann M, Perrior TR, Blundell TL, Spring DR, McKenzie G, Abell C, Skidmore J, Venkitaraman AR, Hyvönen M. Stockwell SR, et al. Among authors: dagostin c. J Med Chem. 2024 Sep 12;67(17):15521-15536. doi: 10.1021/acs.jmedchem.4c01165. Epub 2024 Aug 27. J Med Chem. 2024. PMID: 39190548 Free PMC article.
Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease.
Cai L, Chin FT, Pike VW, Toyama H, Liow JS, Zoghbi SS, Modell K, Briard E, Shetty HU, Sinclair K, Donohue S, Tipre D, Kung MP, Dagostin C, Widdowson DA, Green M, Gao W, Herman MM, Ichise M, Innis RB. Cai L, et al. Among authors: dagostin c. J Med Chem. 2004 Apr 22;47(9):2208-18. doi: 10.1021/jm030477w. J Med Chem. 2004. PMID: 15084119 Free PMC article.
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Scott DE, Francis-Newton NJ, Marsh ME, Coyne AG, Fischer G, Moschetti T, Bayly AR, Sharpe TD, Haas KT, Barber L, Valenzano CR, Srinivasan R, Huggins DJ, Lee M, Emery A, Hardwick B, Ehebauer M, Dagostin C, Esposito A, Pellegrini L, Perrior T, McKenzie G, Blundell TL, Hyvönen M, Skidmore J, Venkitaraman AR, Abell C. Scott DE, et al. Among authors: dagostin c. Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5. doi: 10.1016/j.chembiol.2021.02.006. Epub 2021 Mar 3. Cell Chem Biol. 2021. PMID: 33662256 Free PMC article.
Epicardial Substrate Ablation in Symptomatic Brugada Syndrome Patients: An Updated Systematic Review and Single-arm Meta-analysis.
Karlinski Vizentin V, Felix IF, Pivato da Fonseca R, Bozko Collini M, Pinheiro Braga MA, Dagostin CS, Armaganijan LV, Ackerman MJ, Dantas Brígido AR, Dagostin de Carvalho G. Karlinski Vizentin V, et al. Among authors: dagostin cs. Heart Rhythm. 2025 Jan 10:S1547-5271(25)00020-7. doi: 10.1016/j.hrthm.2025.01.006. Online ahead of print. Heart Rhythm. 2025. PMID: 39800093
Cardiovascular Outcomes of Sodium-Glucose Cotransporter-2 Inhibitors Therapy in Patients With Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Systematic Review and Updated Meta-Analysis.
Felix N, Gauza MM, Teixeira L, Guisso MES, Nogueira A, Dagostin CS, Godoi A, Ribeiro SAG, Duque JC, Moura-Neto JA, Cardoso R. Felix N, et al. Among authors: dagostin cs. Korean Circ J. 2024 Sep;54(9):549-561. doi: 10.4070/kcj.2023.0241. Epub 2024 Apr 26. Korean Circ J. 2024. PMID: 38859642 Free PMC article.
23 results