Deakin AM - Search Results

1

Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.

Alder CM, Ambler M, Campbell AJ, Champigny AC, Deakin AM, Harling JD, Harris CA, Longstaff T, Lynn S, Maxwell AC, Mooney CJ, Scullion C, Singh OM, Smith IE, Somers DO, Tame CJ, Wayne G, Wilson C, Woolven JM. Alder CM, et al. Among authors: deakin am. ACS Med Chem Lett. 2013 Aug 12;4(10):948-52. doi: 10.1021/ml400206q. eCollection 2013 Oct 10. ACS Med Chem Lett. 2013. PMID: 24900590 Free PMC article.

2

Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket.

Harling JD, Deakin AM, Campos S, Grimley R, Chaudry L, Nye C, Polyakova O, Bessant CM, Barton N, Somers D, Barrett J, Graves RH, Hanns L, Kerr WJ, Solari R. Harling JD, et al. Among authors: deakin am. J Biol Chem. 2013 Sep 27;288(39):28195-206. doi: 10.1074/jbc.M113.474114. Epub 2013 Aug 9. J Biol Chem. 2013. PMID: 23935099 Free PMC article.

3

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.

Down K, Amour A, Baldwin IR, Cooper AW, Deakin AM, Felton LM, Guntrip SB, Hardy C, Harrison ZA, Jones KL, Jones P, Keeling SE, Le J, Livia S, Lucas F, Lunniss CJ, Parr NJ, Robinson E, Rowland P, Smith S, Thomas DA, Vitulli G, Washio Y, Hamblin JN. Down K, et al. Among authors: deakin am. J Med Chem. 2015 Sep 24;58(18):7381-99. doi: 10.1021/acs.jmedchem.5b00767. Epub 2015 Sep 3. J Med Chem. 2015. PMID: 26301626

4

Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.

Deakin A, Duddy G, Wilson S, Harrison S, Latcham J, Fulleylove M, Fung S, Smith J, Pedrick M, McKevitt T, Felton L, Morley J, Quint D, Fattah D, Hayes B, Gough J, Solari R. Deakin A, et al. PLoS One. 2014 Sep 24;9(9):e107490. doi: 10.1371/journal.pone.0107490. eCollection 2014. PLoS One. 2014. PMID: 25250764 Free PMC article.

5

The generation and characterization of antagonist RNA aptamers to human oncostatin M.

Rhodes A, Deakin A, Spaull J, Coomber B, Aitken A, Life P, Rees S. Rhodes A, et al. J Biol Chem. 2000 Sep 15;275(37):28555-61. doi: 10.1074/jbc.M002981200. J Biol Chem. 2000. PMID: 10882721 Free article.

6

Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations.

Rice LV, Bax HJ, Russell LJ, Barrett VJ, Walton SE, Deakin AM, Thomson SA, Lucas F, Solari R, House D, Begg M. Rice LV, et al. Among authors: deakin am. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57. doi: 10.1016/j.ejphar.2013.02.022. Epub 2013 Feb 27. Eur J Pharmacol. 2013. PMID: 23454522

7

Kinetic assay for characterization of spleen tyrosine kinase activity and inhibition with recombinant kinase and crude cell lysates.

Li M, Luraghi P, Amour A, Qian XD, Carter PS, Clark CJ, Deakin A, Denyer J, Hobbs CI, Surby M, Patel VK, Schaefer EM. Li M, et al. Anal Biochem. 2009 Jan 1;384(1):56-67. doi: 10.1016/j.ab.2008.07.040. Epub 2008 Aug 15. Anal Biochem. 2009. PMID: 18762159

8

Discovery of novel ansamycins possessing potent inhibitory activity in a cell-based oncostatin M signalling assay.

Stead P, Latif S, Blackaby AP, Sidebottom PJ, Deakin A, Taylor NL, Life P, Spaull J, Burrell F, Jones R, Lewis J, Davidson I, Mander T. Stead P, et al. J Antibiot (Tokyo). 2000 Jul;53(7):657-63. doi: 10.7164/antibiotics.53.657. J Antibiot (Tokyo). 2000. PMID: 10994806 Free article.

9

A lack of evidence for down-modulation of CD3 zeta expression in colorectal carcinoma and pregnancy using multiple detection methods.

Deakin AM, Singh K, Crowe JS, Ellis JH, Dalgleish A, Leicester RJ, Finlayson CJ, Miles WF, Life PF. Deakin AM, et al. Clin Exp Immunol. 1999 Nov;118(2):197-204. doi: 10.1046/j.1365-2249.1999.01044.x. Clin Exp Immunol. 1999. PMID: 10540179 Free PMC article.

10

Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat.

Boughton-Smith NK, Hutcheson IR, Deakin AM, Whittle BJ, Moncada S. Boughton-Smith NK, et al. Among authors: deakin am. Eur J Pharmacol. 1990 Dec 4;191(3):485-8. doi: 10.1016/0014-2999(90)94185-z. Eur J Pharmacol. 1990. PMID: 2086252

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