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A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.
van der Schaar HM, Leyssen P, Thibaut HJ, de Palma A, van der Linden L, Lanke KH, Lacroix C, Verbeken E, Conrath K, Macleod AM, Mitchell DR, Palmer NJ, van de Poël H, Andrews M, Neyts J, van Kuppeveld FJ. van der Schaar HM, et al. Among authors: macleod am. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81. doi: 10.1128/AAC.01175-13. Epub 2013 Jul 29. Antimicrob Agents Chemother. 2013. PMID: 23896472 Free PMC article.
A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.
Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y. Alagramam KN, et al. Among authors: macleod am. Nat Chem Biol. 2016 Jun;12(6):444-51. doi: 10.1038/nchembio.2069. Epub 2016 Apr 25. Nat Chem Biol. 2016. PMID: 27110679 Free PMC article.
A national pilot of donation after circulatory death (DCD) heart transplantation within the United Kingdom.
Messer S, Rushton S, Simmonds L, Macklam D, Husain M, Jothidasan A, Large S, Tsui S, Kaul P, Baxter J, Osman M, Mehta V, Russell D, Stock U, Dunning J, Saez DG, Venkateswaran R, Curry P, Ayton L, Mukadam M, Mascaro J, Simmonds J, Macgowan G, Clark S, Jungschleger J, Reinhardt Z, Quigley R, Speed J, Parameshwar J, Jenkins D, Watson S, Marley F, Ali A, Gardiner D, Rubino A, Whitney J, Beale S, Slater C, Currie I, Armstrong L, Foley J, Ryan M, Gibson S, Quinn K, Macleod AM, Spence S, Watson CJE, Catarino P, Clarkson A, Forsythe J, Manas D, Berman M. Messer S, et al. Among authors: macleod am. J Heart Lung Transplant. 2023 Aug;42(8):1120-1130. doi: 10.1016/j.healun.2023.03.006. Epub 2023 Mar 13. J Heart Lung Transplant. 2023. PMID: 37032222 Free article.
Discovery of ONO-8590580: A novel, potent and selective GABAA α5 negative allosteric modulator for the treatment of cognitive disorders.
Lewis A, Beresford A, Chambers MS, Clark G, Hartley DC, Hirst KL, Higashino M, Kawahadara S, Nakanishi M, Saito T, Imagawa A, Habashita H, Maidment S, Macleod AM, Owens AP, Rae A, Rouse C, Wishart G. Lewis A, et al. Among authors: macleod am. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127536. doi: 10.1016/j.bmcl.2020.127536. Epub 2020 Sep 6. Bioorg Med Chem Lett. 2020. PMID: 32898695
243 results