Walkinshaw MD - Search Results

1

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.

Brimacombe KR, Walsh MJ, Liu L, Vásquez-Valdivieso MG, Morgan HP, McNae I, Fothergill-Gilmore LA, Michels PA, Auld DS, Simeonov A, Walkinshaw MD, Shen M, Boxer MB. Brimacombe KR, et al. Among authors: walkinshaw md. ACS Med Chem Lett. 2013 Oct 30;5(1):12-7. doi: 10.1021/ml400259d. eCollection 2014 Jan 9. ACS Med Chem Lett. 2013. PMID: 24900769 Free PMC article.

2

The first crystal structure of phosphofructokinase from a eukaryote: Trypanosoma brucei.

Martinez-Oyanedel J, McNae IW, Nowicki MW, Keillor JW, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD. Martinez-Oyanedel J, et al. Among authors: walkinshaw md. J Mol Biol. 2007 Mar 2;366(4):1185-98. doi: 10.1016/j.jmb.2006.10.019. Epub 2006 Oct 11. J Mol Biol. 2007. PMID: 17207816

3

Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis.

Nowicki MW, Tulloch LB, Worralll L, McNae IW, Hannaert V, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD, Turner NJ. Nowicki MW, et al. Among authors: walkinshaw md. Bioorg Med Chem. 2008 May 1;16(9):5050-61. doi: 10.1016/j.bmc.2008.03.045. Epub 2008 Mar 21. Bioorg Med Chem. 2008. PMID: 18387804

4

The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases.

McNae IW, Martinez-Oyanedel J, Keillor JW, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD. McNae IW, et al. Among authors: walkinshaw md. J Mol Biol. 2009 Feb 6;385(5):1519-33. doi: 10.1016/j.jmb.2008.11.047. Epub 2008 Dec 3. J Mol Biol. 2009. PMID: 19084537

5

Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model.

Morgan HP, McNae IW, Nowicki MW, Hannaert V, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD. Morgan HP, et al. Among authors: walkinshaw md. J Biol Chem. 2010 Apr 23;285(17):12892-8. doi: 10.1074/jbc.M109.079905. Epub 2010 Feb 1. J Biol Chem. 2010. PMID: 20123988 Free PMC article.

6

The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.

Morgan HP, McNae IW, Nowicki MW, Zhong W, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD. Morgan HP, et al. Among authors: walkinshaw md. J Biol Chem. 2011 Sep 9;286(36):31232-40. doi: 10.1074/jbc.M110.212613. Epub 2011 Jul 5. J Biol Chem. 2011. PMID: 21733839 Free PMC article.

7

Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo.

Fuad FA, Fothergill-Gilmore LA, Nowicki MW, Eades LJ, Morgan HP, McNae IW, Michels PA, Walkinshaw MD. Fuad FA, et al. Among authors: walkinshaw md. Metallomics. 2011 Dec;3(12):1310-7. doi: 10.1039/c1mt00119a. Epub 2011 Oct 13. Metallomics. 2011. PMID: 21993954

8

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

Morgan HP, Walsh MJ, Blackburn EA, Wear MA, Boxer MB, Shen M, Veith H, McNae IW, Nowicki MW, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD. Morgan HP, et al. Among authors: walkinshaw md. Biochem J. 2012 Nov 15;448(1):67-72. doi: 10.1042/BJ20121014. Biochem J. 2012. PMID: 22906073 Free PMC article.

9

`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.

Zhong W, Morgan HP, McNae IW, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD. Zhong W, et al. Among authors: walkinshaw md. Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1768-79. doi: 10.1107/S0907444913013875. Epub 2013 Aug 17. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23999300

10

Pyruvate kinases have an intrinsic and conserved decarboxylase activity.

Zhong W, Morgan HP, Nowicki MW, McNae IW, Yuan M, Bella J, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD. Zhong W, et al. Among authors: walkinshaw md. Biochem J. 2014 Mar 1;458(2):301-11. doi: 10.1042/BJ20130790. Biochem J. 2014. PMID: 24328825 Free article.

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