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Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.
Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. Dandapani S, et al. Among authors: gut j. ACS Med Chem Lett. 2013 Dec 29;5(2):149-53. doi: 10.1021/ml400403u. eCollection 2014 Feb 13. ACS Med Chem Lett. 2013. PMID: 24900788 Free PMC article.
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: gut j. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423
Antiparasitic activities of novel, orally available fumagillin analogs.
Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK. Arico-Muendel C, et al. Among authors: gut j. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. doi: 10.1016/j.bmcl.2009.07.029. Epub 2009 Jul 10. Bioorg Med Chem Lett. 2009. PMID: 19648008 Free PMC article.
Mining a cathepsin inhibitor library for new antiparasitic drug leads.
Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Ang KK, et al. Among authors: gut j. PLoS Negl Trop Dis. 2011 May 3;5(5):e1023. doi: 10.1371/journal.pntd.0001023. PLoS Negl Trop Dis. 2011. PMID: 21572521 Free PMC article.
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.
Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. Gunatilleke SS, et al. Among authors: gut j. PLoS Negl Trop Dis. 2012;6(7):e1736. doi: 10.1371/journal.pntd.0001736. Epub 2012 Jul 31. PLoS Negl Trop Dis. 2012. PMID: 22860142 Free PMC article.
314 results