Norman RA - Search Results

1

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures.

Klein T, Tucker J, Holdgate GA, Norman RA, Breeze AL. Klein T, et al. Among authors: norman ra. ACS Med Chem Lett. 2013 Dec 6;5(2):166-71. doi: 10.1021/ml4004205. eCollection 2014 Feb 13. ACS Med Chem Lett. 2013. PMID: 24900792 Free PMC article.

2

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation.

Ward RA, Brassington C, Breeze AL, Caputo A, Critchlow S, Davies G, Goodwin L, Hassall G, Greenwood R, Holdgate GA, Mrosek M, Norman RA, Pearson S, Tart J, Tucker JA, Vogtherr M, Whittaker D, Wingfield J, Winter J, Hudson K. Ward RA, et al. Among authors: norman ra. J Med Chem. 2012 Apr 12;55(7):3285-306. doi: 10.1021/jm201734r. Epub 2012 Mar 26. J Med Chem. 2012. PMID: 22417091

3

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4.

Tucker JA, Klein T, Breed J, Breeze AL, Overman R, Phillips C, Norman RA. Tucker JA, et al. Among authors: norman ra. Structure. 2014 Dec 2;22(12):1764-1774. doi: 10.1016/j.str.2014.09.019. Epub 2014 Nov 20. Structure. 2014. PMID: 25465127 Free article.

4

Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors.

Byth KF, Cooper N, Culshaw JD, Heaton DW, Oakes SE, Minshull CA, Norman RA, Pauptit RA, Tucker JA, Breed J, Pannifer A, Rowsell S, Stanway JJ, Valentine AL, Thomas AP. Byth KF, et al. Among authors: norman ra. Bioorg Med Chem Lett. 2004 May 3;14(9):2249-52. doi: 10.1016/j.bmcl.2004.02.008. Bioorg Med Chem Lett. 2004. PMID: 15081018

5

Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.

Sullivan JE, Holdgate GA, Campbell D, Timms D, Gerhardt S, Breed J, Breeze AL, Bermingham A, Pauptit RA, Norman RA, Embrey KJ, Read J, VanScyoc WS, Ward WH. Sullivan JE, et al. Among authors: norman ra. Biochemistry. 2005 Dec 20;44(50):16475-90. doi: 10.1021/bi051714v. Biochemistry. 2005. PMID: 16342939

6

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase.

Klein T, Vajpai N, Phillips JJ, Davies G, Holdgate GA, Phillips C, Tucker JA, Norman RA, Scott AD, Higazi DR, Lowe D, Thompson GS, Breeze AL. Klein T, et al. Among authors: norman ra. Nat Commun. 2015 Jul 23;6:7877. doi: 10.1038/ncomms8877. Nat Commun. 2015. PMID: 26203596 Free PMC article.

7

Validation of ion mobility spectrometry - mass spectrometry as a screening tool to identify type II kinase inhibitors of FGFR1 kinase.

Beeston HS, Klein T, Norman RA, Tucker JA, Anderson M, Ashcroft AE, Holdgate GA. Beeston HS, et al. Among authors: norman ra. Rapid Commun Mass Spectrom. 2021 May 26:e9130. doi: 10.1002/rcm.9130. Online ahead of print. Rapid Commun Mass Spectrom. 2021. PMID: 34038603

8

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.

Patani H, Bunney TD, Thiyagarajan N, Norman RA, Ogg D, Breed J, Ashford P, Potterton A, Edwards M, Williams SV, Thomson GS, Pang CS, Knowles MA, Breeze AL, Orengo C, Phillips C, Katan M. Patani H, et al. Among authors: norman ra. Oncotarget. 2016 Apr 26;7(17):24252-68. doi: 10.18632/oncotarget.8132. Oncotarget. 2016. PMID: 26992226 Free PMC article.

9

Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor.

Norman RA, Barry ST, Bate M, Breed J, Colls JG, Ernill RJ, Luke RW, Minshull CA, McAlister MS, McCall EJ, McMiken HH, Paterson DS, Timms D, Tucker JA, Pauptit RA. Norman RA, et al. Structure. 2004 Jan;12(1):75-84. doi: 10.1016/j.str.2003.11.018. Structure. 2004. PMID: 14725767 Free article.

10

Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase.

Norman RA, Schott AK, Andrews DM, Breed J, Foote KM, Garner AP, Ogg D, Orme JP, Pink JH, Roberts K, Rudge DA, Thomas AP, Leach AG. Norman RA, et al. J Med Chem. 2012 Jun 14;55(11):5003-12. doi: 10.1021/jm3004043. Epub 2012 May 21. J Med Chem. 2012. PMID: 22612866

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