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318 results

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Page 1
Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa.
Takeoka Y, Tanino T, Sekiguchi M, Yonezawa S, Sakagami M, Takahashi F, Togame H, Tanaka Y, Takemoto H, Ichikawa S, Matsuda A. Takeoka Y, et al. Among authors: takemoto h. ACS Med Chem Lett. 2014 Mar 6;5(5):556-60. doi: 10.1021/ml5000096. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900879 Free PMC article.
Conformational restriction approach to β-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
Yonezawa S, Yamamoto T, Yamakawa H, Muto C, Hosono M, Hattori K, Higashino K, Yutsudo T, Iwamoto H, Kondo Y, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: takemoto h. J Med Chem. 2012 Oct 25;55(20):8838-58. doi: 10.1021/jm3011405. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998419
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction.
Okamoto K, Sakagami M, Feng F, Takahashi F, Uotani K, Togame H, Takemoto H, Ichikawa S, Matsuda A. Okamoto K, et al. Among authors: takemoto h. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4810-5. doi: 10.1016/j.bmcl.2012.05.050. Epub 2012 May 18. Bioorg Med Chem Lett. 2012. PMID: 22677318
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.
Yonezawa S, Yamakawa H, Muto C, Hosono M, Yamamoto T, Hattori K, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: takemoto h. Bioorg Med Chem Lett. 2013 May 15;23(10):2912-5. doi: 10.1016/j.bmcl.2013.03.056. Epub 2013 Mar 26. Bioorg Med Chem Lett. 2013. PMID: 23562056
Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.
Arioka S, Sakagami M, Uematsu R, Yamaguchi H, Togame H, Takemoto H, Hinou H, Nishimura S. Arioka S, et al. Among authors: takemoto h. Bioorg Med Chem. 2010 Feb 15;18(4):1633-40. doi: 10.1016/j.bmc.2009.12.062. Epub 2010 Jan 6. Bioorg Med Chem. 2010. PMID: 20097567
Conformational restriction approach to β-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
Yonezawa S, Fujiwara K, Yamamoto T, Hattori K, Yamakawa H, Muto C, Hosono M, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: takemoto h. Bioorg Med Chem. 2013 Nov 1;21(21):6506-22. doi: 10.1016/j.bmc.2013.08.036. Epub 2013 Aug 28. Bioorg Med Chem. 2013. PMID: 24051074
Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics.
Ishihara T, Kakiya K, Takahashi K, Miwa H, Rokushima M, Yoshinaga T, Tanaka Y, Ito T, Togame H, Takemoto H, Amano M, Iwasaki N, Minami A, Nishimura S. Ishihara T, et al. Among authors: takemoto h. Biochim Biophys Acta. 2014 Jan;1840(1):645-55. doi: 10.1016/j.bbagen.2013.10.027. Epub 2013 Oct 24. Biochim Biophys Acta. 2014. PMID: 24161698
318 results