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Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients.
Hammond TG, Meng X, Jenkins RE, Maggs JL, Castelazo AS, Regan SL, Bennett SN, Earnshaw CJ, Aithal GP, Pande I, Kenna JG, Stachulski AV, Park BK, Williams DP. Hammond TG, et al. Among authors: williams dp. J Pharmacol Exp Ther. 2014 Aug;350(2):387-402. doi: 10.1124/jpet.114.215079. Epub 2014 Jun 5. J Pharmacol Exp Ther. 2014. PMID: 24902585 Free PMC article.
Acyl glucuronides: the good, the bad and the ugly.
Regan SL, Maggs JL, Hammond TG, Lambert C, Williams DP, Park BK. Regan SL, et al. Among authors: williams dp. Biopharm Drug Dispos. 2010 Oct;31(7):367-95. doi: 10.1002/bdd.720. Biopharm Drug Dispos. 2010. PMID: 20830700 Review.
The role of metabolic activation in drug-induced hepatotoxicity.
Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP. Park BK, et al. Among authors: williams dp. Annu Rev Pharmacol Toxicol. 2005;45:177-202. doi: 10.1146/annurev.pharmtox.45.120403.100058. Annu Rev Pharmacol Toxicol. 2005. PMID: 15822174 Review.
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.
Mercer AE, Regan SL, Hirst CM, Graham EE, Antoine DJ, Benson CA, Williams DP, Foster J, Kenna JG, Park BK. Mercer AE, et al. Among authors: williams dp. Toxicol Appl Pharmacol. 2009 Sep 15;239(3):297-305. doi: 10.1016/j.taap.2009.05.027. Epub 2009 Jun 10. Toxicol Appl Pharmacol. 2009. PMID: 19523481
210 results