Arkin MR - Search Results

1

Screening for noise in gene expression identifies drug synergies.

Dar RD, Hosmane NN, Arkin MR, Siliciano RF, Weinberger LS. Dar RD, et al. Among authors: arkin mr. Science. 2014 Jun 20;344(6190):1392-6. doi: 10.1126/science.1250220. Epub 2014 Jun 5. Science. 2014. PMID: 24903562 Free PMC article.

2

Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation.

Jiang Z, Kuo YH, Arkin MR. Jiang Z, et al. Among authors: arkin mr. J Am Chem Soc. 2023 Nov 8;145(44):23939-23947. doi: 10.1021/jacs.3c05199. Epub 2023 Sep 25. J Am Chem Soc. 2023. PMID: 37748140 Free PMC article.

3

From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.

Visser EJ, Jaishankar P, Sijbesma E, Pennings MAM, Vandenboorn EMF, Guillory X, Neitz RJ, Morrow J, Dutta S, Renslo AR, Brunsveld L, Arkin MR, Ottmann C. Visser EJ, et al. Among authors: arkin mr. Angew Chem Int Ed Engl. 2023 Sep 11;62(37):e202308004. doi: 10.1002/anie.202308004. Epub 2023 Aug 1. Angew Chem Int Ed Engl. 2023. PMID: 37455289 Free PMC article.

4

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.

Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S. Banerjee S, et al. Science. 2016 Feb 19;351(6275):871-5. doi: 10.1126/science.aad7974. Epub 2016 Jan 28. Science. 2016. PMID: 26822609 Free PMC article.

5

A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit.

De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. De Muylder G, et al. Among authors: arkin mr. PLoS Negl Trop Dis. 2011 Jul;5(7):e1253. doi: 10.1371/journal.pntd.0001253. Epub 2011 Jul 19. PLoS Negl Trop Dis. 2011. PMID: 21811648 Free PMC article.

6

A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.

Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL Jr. Bagriantsev SN, et al. Among authors: arkin mr. ACS Chem Biol. 2013 Aug 16;8(8):1841-51. doi: 10.1021/cb400289x. Epub 2013 Jun 17. ACS Chem Biol. 2013. PMID: 23738709 Free PMC article.

7

Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases.

Flygare JA, Arkin MR. Flygare JA, et al. Among authors: arkin mr. Curr Top Med Chem. 2014;14(3):319-25. doi: 10.2174/1568026613666131126224039. Curr Top Med Chem. 2014. PMID: 24283214 Review.

8

UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area.

Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. Arkin MR, et al. Comb Chem High Throughput Screen. 2014 May;17(4):333-42. doi: 10.2174/1386207317666140323133841. Comb Chem High Throughput Screen. 2014. PMID: 24661212

9

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

Arkin MR, Tang Y, Wells JA. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. doi: 10.1016/j.chembiol.2014.09.001. Chem Biol. 2014. PMID: 25237857 Free PMC article. Review.

10

Lead identification to clinical candidate selection: drugs for Chagas disease.

Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. Neitz RJ, et al. J Biomol Screen. 2015 Jan;20(1):101-11. doi: 10.1177/1087057114553103. Epub 2014 Oct 3. J Biomol Screen. 2015. PMID: 25281737

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