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Page 1
Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on single-ascending-dose study data with AZD3839.
Sparve E, Quartino AL, Lüttgen M, Tunblad K, Gårdlund AT, Fälting J, Alexander R, Kågström J, Sjödin L, Bulgak A, Al-Saffar A, Bridgland-Taylor M, Pollard C, Swedberg MD, Vik T, Paulsson B. Sparve E, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):469-78. doi: 10.1124/jpet.114.215202. Epub 2014 Jun 10. J Pharmacol Exp Ther. 2014. PMID: 24917547 Free article. Clinical Trial.
Population pharmacokinetic and pharmacodynamic analysis of plasma Aβ40 and Aβ42 following single oral doses of the BACE1 inhibitor AZD3839 to healthy volunteers.
Quartino A, Huledal G, Sparve E, Lüttgen M, Bueters T, Karlsson P, Olsson T, Paraskos J, Maltby J, Claeson-Bohnstedt K, Lee CM, Alexander R, Fälting J, Paulsson B. Quartino A, et al. Among authors: sparve e. Clin Pharmacol Drug Dev. 2014 Sep;3(5):396-405. doi: 10.1002/cpdd.130. Epub 2014 May 26. Clin Pharmacol Drug Dev. 2014. PMID: 27129013 Clinical Trial.
Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol.
Kanebratt KP, Diczfalusy U, Bäckström T, Sparve E, Bredberg E, Böttiger Y, Andersson TB, Bertilsson L. Kanebratt KP, et al. Among authors: sparve e. Clin Pharmacol Ther. 2008 Nov;84(5):589-94. doi: 10.1038/clpt.2008.132. Epub 2008 Jul 23. Clin Pharmacol Ther. 2008. PMID: 18650803 Clinical Trial.
Long-term safety and outcomes in hereditary tyrosinaemia type 1 with nitisinone treatment: a 15-year non-interventional, multicentre study.
Spiekerkoetter U, Couce ML, Das AM, de Laet C, Dionisi-Vici C, Lund AM, Schiff M, Spada M, Sparve E, Szamosi J, Vara R, Rudebeck M. Spiekerkoetter U, et al. Among authors: sparve e. Lancet Diabetes Endocrinol. 2021 Jul;9(7):427-435. doi: 10.1016/S2213-8587(21)00092-9. Epub 2021 May 21. Lancet Diabetes Endocrinol. 2021. PMID: 34023005 Clinical Trial.
Acute clozapine intoxication.
Sparve E, Nordberg P, Forsberg S, Helldén A. Sparve E, et al. J Clin Psychopharmacol. 2009 Jun;29(3):302-4. doi: 10.1097/JCP.0b013e3181a20c73. J Clin Psychopharmacol. 2009. PMID: 19440090 No abstract available.