Abdelsamie AS - Search Results

1

Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker.

Abdelsamie AS, Bey E, Hanke N, Empting M, Hartmann RW, Frotscher M. Abdelsamie AS, et al. Eur J Med Chem. 2014 Jul 23;82:394-406. doi: 10.1016/j.ejmech.2014.05.074. Epub 2014 Jun 3. Eur J Med Chem. 2014. PMID: 24929290

2

Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor.

Galal SA, Abdelsamie AS, Soliman SM, Mortier J, Wolber G, Ali MM, Tokuda H, Suzuki N, Lida A, Ramadan RA, El Diwani HI. Galal SA, et al. Among authors: abdelsamie as. Eur J Med Chem. 2013 Nov;69:115-24. doi: 10.1016/j.ejmech.2013.07.049. Epub 2013 Aug 13. Eur J Med Chem. 2013. PMID: 24013411

3

Design, synthesis and molecular docking study of novel quinoxalin-2(1H)-ones as anti-tumor active agents with inhibition of tyrosine kinase receptor and studying their cyclooxygenase-2 activity.

Galal SA, Khairat SH, Ragab FA, Abdelsamie AS, Ali MM, Soliman SM, Mortier J, Wolber G, El Diwani HI. Galal SA, et al. Among authors: abdelsamie as. Eur J Med Chem. 2014 Oct 30;86:122-32. doi: 10.1016/j.ejmech.2014.08.048. Epub 2014 Aug 15. Eur J Med Chem. 2014. PMID: 25147154

4

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme.

Abdelsamie AS, Bey E, Gargano EM, van Koppen CJ, Empting M, Frotscher M. Abdelsamie AS, et al. Eur J Med Chem. 2015 Oct 20;103:56-68. doi: 10.1016/j.ejmech.2015.08.030. Epub 2015 Aug 18. Eur J Med Chem. 2015. PMID: 26322835

5

Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC₅₀ for a proof-of-principle study.

Abdelsamie AS, van Koppen CJ, Bey E, Salah M, Börger C, Siebenbürger L, Laschke MW, Menger MD, Frotscher M. Abdelsamie AS, et al. Eur J Med Chem. 2017 Feb 15;127:944-957. doi: 10.1016/j.ejmech.2016.11.004. Epub 2016 Nov 4. Eur J Med Chem. 2017. PMID: 27852458

6

First Structure-Activity Relationship of 17β-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.

Braun F, Bertoletti N, Möller G, Adamski J, Steinmetzer T, Salah M, Abdelsamie AS, van Koppen CJ, Heine A, Klebe G, Marchais-Oberwinkler S. Braun F, et al. Among authors: abdelsamie as. J Med Chem. 2016 Dec 8;59(23):10719-10737. doi: 10.1021/acs.jmedchem.6b01436. Epub 2016 Nov 18. J Med Chem. 2016. PMID: 27933965

7

First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases.

Salah M, Abdelsamie AS, Frotscher M. Salah M, et al. Among authors: abdelsamie as. J Med Chem. 2017 May 11;60(9):4086-4092. doi: 10.1021/acs.jmedchem.7b00062. Epub 2017 Apr 27. J Med Chem. 2017. PMID: 28406629

8

Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs.

Galal SA, Abdelsamie AS, Shouman SA, Attia YM, Ali HI, Tabll A, El-Shenawy R, El Abd YS, Ali MM, Mahmoud AE, Abdel-Halim AH, Fyiad AA, Girgis AS, El-Diwani HI. Galal SA, et al. Among authors: abdelsamie as. Eur J Med Chem. 2017 Jul 7;134:392-405. doi: 10.1016/j.ejmech.2017.03.090. Epub 2017 Apr 14. Eur J Med Chem. 2017. PMID: 28433679

9

Inhibitors of 17β-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges.

Salah M, Abdelsamie AS, Frotscher M. Salah M, et al. Among authors: abdelsamie as. Mol Cell Endocrinol. 2019 Jun 1;489:66-81. doi: 10.1016/j.mce.2018.10.001. Epub 2018 Oct 15. Mol Cell Endocrinol. 2019. PMID: 30336189 Review.

10

Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy.

Siebenbuerger L, Hernandez-Olmos V, Abdelsamie AS, Frotscher M, van Koppen CJ, Marchais-Oberwinkler S, Scheuer C, Laschke MW, Menger MD, Boerger C, Hartmann RW. Siebenbuerger L, et al. Among authors: abdelsamie as. J Med Chem. 2018 Dec 13;61(23):10724-10738. doi: 10.1021/acs.jmedchem.8b01373. Epub 2018 Nov 27. J Med Chem. 2018. PMID: 30480443

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