Dean T - Search Results

1

Backbone modification of a polypeptide drug alters duration of action in vivo.

Cheloha RW, Maeda A, Dean T, Gardella TJ, Gellman SH. Cheloha RW, et al. Among authors: dean t. Nat Biotechnol. 2014 Jul;32(7):653-5. doi: 10.1038/nbt.2920. Epub 2014 Jun 15. Nat Biotechnol. 2014. PMID: 24929976 Free PMC article.

2

Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3.

Shimizu N, Dean T, Khatri A, Gardella TJ. Shimizu N, et al. Among authors: dean t. J Bone Miner Res. 2004 Dec;19(12):2078-86. doi: 10.1359/JBMR.040914. Epub 2004 Sep 20. J Bone Miner Res. 2004. PMID: 15537452 Free article.

3

Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptor.

Shimizu N, Dean T, Tsang JC, Khatri A, Potts JT Jr, Gardella TJ. Shimizu N, et al. Among authors: dean t. J Biol Chem. 2005 Jan 21;280(3):1797-807. doi: 10.1074/jbc.M408270200. Epub 2004 Nov 17. J Biol Chem. 2005. PMID: 15550385 Free article.

4

Backbone-methylated analogues of the principle receptor binding region of human parathyroid hormone. Evidence for binding to both the N-terminal extracellular domain and extracellular loop region.

Barbier JR, Gardella TJ, Dean T, MacLean S, Potetinova Z, Whitfield JF, Willick GE. Barbier JR, et al. Among authors: dean t. J Biol Chem. 2005 Jun 24;280(25):23771-7. doi: 10.1074/jbc.M500817200. Epub 2005 Apr 11. J Biol Chem. 2005. PMID: 15826940 Free article.

5

Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations.

Dean T, Linglart A, Mahon MJ, Bastepe M, Jüppner H, Potts JT Jr, Gardella TJ. Dean T, et al. Mol Endocrinol. 2006 Apr;20(4):931-43. doi: 10.1210/me.2005-0349. Epub 2005 Dec 8. Mol Endocrinol. 2006. PMID: 16339275 Free PMC article.

6

Role of amino acid side chains in region 17-31 of parathyroid hormone (PTH) in binding to the PTH receptor.

Dean T, Khatri A, Potetinova Z, Willick GE, Gardella TJ. Dean T, et al. J Biol Chem. 2006 Oct 27;281(43):32485-95. doi: 10.1074/jbc.M606179200. Epub 2006 Aug 21. J Biol Chem. 2006. PMID: 16923805 Free article.

7

C-terminal analogues of parathyroid hormone: effect of C-terminus function on helical structure, stability, and bioactivity.

Potetinova Z, Barbier JR, Suen T, Dean T, Gardella TJ, Willick GE. Potetinova Z, et al. Among authors: dean t. Biochemistry. 2006 Sep 19;45(37):11113-21. doi: 10.1021/bi060500q. Biochemistry. 2006. PMID: 16964972

8

Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.

Dean T, Vilardaga JP, Potts JT Jr, Gardella TJ. Dean T, et al. Mol Endocrinol. 2008 Jan;22(1):156-66. doi: 10.1210/me.2007-0274. Epub 2007 Sep 13. Mol Endocrinol. 2008. PMID: 17872377 Free PMC article.

9

Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs.

Nagai S, Okazaki M, Segawa H, Bergwitz C, Dean T, Potts JT Jr, Mahon MJ, Gardella TJ, Jüppner H. Nagai S, et al. Among authors: dean t. J Biol Chem. 2011 Jan 14;286(2):1618-26. doi: 10.1074/jbc.M110.198416. Epub 2010 Nov 3. J Biol Chem. 2011. PMID: 21047792 Free PMC article.

10

Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.

Dong S, Shang S, Li J, Tan Z, Dean T, Maeda A, Gardella TJ, Danishefsky SJ. Dong S, et al. Among authors: dean t. J Am Chem Soc. 2012 Sep 12;134(36):15122-9. doi: 10.1021/ja306637u. Epub 2012 Aug 29. J Am Chem Soc. 2012. PMID: 22891619 Free PMC article.

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