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2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1.
Carreño R, Brown WS, Li D, Hernandez JA, Wang Y, Kim TK, Craft JW Jr, Komanduri KV, Radvanyi LG, Hwu P, Molldrem JJ, Legge GB, McIntyre BW, Ma Q. Carreño R, et al. Among authors: brown ws. J Biol Chem. 2010 Oct 22;285(43):32860-32868. doi: 10.1074/jbc.M110.111591. Epub 2010 Aug 19. J Biol Chem. 2010. PMID: 20724473 Free PMC article.
Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion.
Vanderslice P, Biediger RJ, Woodside DG, Brown WS, Khounlo S, Warier ND, Gundlach CW 4th, Caivano AR, Bornmann WG, Maxwell DS, McIntyre BW, Willerson JT, Dixon RA. Vanderslice P, et al. Among authors: brown ws. J Biol Chem. 2013 Jul 5;288(27):19414-28. doi: 10.1074/jbc.M113.479634. Epub 2013 May 23. J Biol Chem. 2013. PMID: 23703610 Free PMC article.
The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells.
Fiorcari S, Brown WS, McIntyre BW, Estrov Z, Maffei R, O'Brien S, Sivina M, Hoellenriegel J, Wierda WG, Keating MJ, Ding W, Kay NE, Lannutti BJ, Marasca R, Burger JA. Fiorcari S, et al. Among authors: brown ws. PLoS One. 2013 Dec 23;8(12):e83830. doi: 10.1371/journal.pone.0083830. eCollection 2013. PLoS One. 2013. PMID: 24376763 Free PMC article.
Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis.
Lee YC, Jin JK, Cheng CJ, Huang CF, Song JH, Huang M, Brown WS, Zhang S, Yu-Lee LY, Yeh ET, McIntyre BW, Logothetis CJ, Gallick GE, Lin SH. Lee YC, et al. Among authors: brown ws. Mol Cancer Res. 2013 Apr;11(4):405-17. doi: 10.1158/1541-7786.MCR-12-0551. Epub 2013 Jan 21. Mol Cancer Res. 2013. PMID: 23339185 Free PMC article.
Synthesis and evaluation of an anti-MLC1 × anti-CD90 bispecific antibody for targeting and retaining bone-marrow-derived multipotent stromal cells in infarcted myocardium.
Gundlach CW 4th, Caivano A, Cabreira-Hansen Mda G, Gahremanpour A, Brown WS, Zheng Y, McIntyre BW, Willerson JT, Dixon RA, Perin EC, Woodside DG. Gundlach CW 4th, et al. Among authors: brown ws. Bioconjug Chem. 2011 Aug 17;22(8):1706-14. doi: 10.1021/bc200309h. Epub 2011 Aug 2. Bioconjug Chem. 2011. PMID: 21749133 Free PMC article.
Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.
McDonald PC, Chafe SC, Brown WS, Saberi S, Swayampakula M, Venkateswaran G, Nemirovsky O, Gillespie JA, Karasinska JM, Kalloger SE, Supuran CT, Schaeffer DF, Bashashati A, Shah SP, Topham JT, Yapp DT, Li J, Renouf DJ, Stanger BZ, Dedhar S. McDonald PC, et al. Among authors: brown ws. Gastroenterology. 2019 Sep;157(3):823-837. doi: 10.1053/j.gastro.2019.05.004. Epub 2019 May 9. Gastroenterology. 2019. PMID: 31078621 Free article.
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