Tombs L - Search Results

1

Effects of moderate hepatic impairment on the pharmacokinetic properties and tolerability of umeclidinium and vilanterol in inhalational umeclidinium monotherapy and umeclidinium/vilanterol combination therapy: an open-label, nonrandomized study.

Mehta R, Hardes K, Kelleher D, Preece A, Tombs L, Brealey N. Mehta R, et al. Among authors: tombs l. Clin Ther. 2014 Jul 1;36(7):1016-1027.e2. doi: 10.1016/j.clinthera.2014.05.002. Epub 2014 Jun 17. Clin Ther. 2014. PMID: 24947493 Clinical Trial.

2

Any Decrease in Lung Function is Associated With Worse Clinical Outcomes: Post Hoc Analysis of the IMPACT Interventional Trial.

Han MK, Criner GJ, Halpin DMG, Kerwin EM, Tombs L, Lipson DA, Martinez FJ, Wise RA, Singh D. Han MK, et al. Among authors: tombs l. Chronic Obstr Pulm Dis. 2024 Jan 25;11(1):106-113. doi: 10.15326/jcopdf.2023.0391. Chronic Obstr Pulm Dis. 2024. PMID: 38081161 Free PMC article.

3

ECG-based risk factors for adverse cardiopulmonary events and treatment outcomes in COPD.

Wade RC, Martinez FJ, Criner GJ, Tombs L, Lipson DA, Halpin DMG, Han MK, Singh D, Wise RA, Kalhan R, Dransfield MT. Wade RC, et al. Among authors: tombs l. Eur Respir J. 2024 Nov 21:2400171. doi: 10.1183/13993003.00171-2024. Online ahead of print. Eur Respir J. 2024. PMID: 39467609 Free article.

4

The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of inhaled fluticasone furoate and vilanterol trifenatate in healthy subjects.

Kempsford R, Allen A, Bal J, Rubin D, Tombs L. Kempsford R, et al. Among authors: tombs l. Br J Clin Pharmacol. 2013 Jun;75(6):1478-87. doi: 10.1111/bcp.12019. Br J Clin Pharmacol. 2013. PMID: 23116485 Free PMC article. Clinical Trial.

5

Influence of renal and hepatic impairment on the pharmacokinetic and pharmacodynamic properties and tolerability of fluticasone furoate and vilanterol in combination.

Allen A, Davis A, Hardes K, Tombs L, Kempsford R. Allen A, et al. Among authors: tombs l. Clin Ther. 2012 Dec;34(12):2316-32. doi: 10.1016/j.clinthera.2012.11.001. Epub 2012 Nov 30. Clin Ther. 2012. PMID: 23200625 Clinical Trial.

6

The efficacy of once-daily fluticasone furoate/vilanterol in asthma is comparable with morning or evening dosing.

Kempsford RD, Oliver A, Bal J, Tombs L, Quinn D. Kempsford RD, et al. Among authors: tombs l. Respir Med. 2013 Dec;107(12):1873-80. doi: 10.1016/j.rmed.2013.07.002. Epub 2013 Nov 5. Respir Med. 2013. PMID: 24200619 Free article. Clinical Trial.

7

Tolerability of fluticasone furoate/vilanterol combination therapy in children aged 5 to 11 years with persistent asthma.

Oliver A, VanBuren S, Allen A, Hamilton M, Tombs L, Inamdar A, Kempsford R. Oliver A, et al. Among authors: tombs l. Clin Ther. 2014 Jun 1;36(6):928-939.e1. doi: 10.1016/j.clinthera.2014.03.014. Epub 2014 Apr 30. Clin Ther. 2014. PMID: 24793536 Free article. Clinical Trial.

8

A randomized, placebo- and moxifloxacin-controlled thorough QT study of umeclidinium monotherapy and umeclidinium/vilanterol combination in healthy subjects.

Kelleher D, Tombs L, Preece A, Brealey N, Mehta R. Kelleher D, et al. Among authors: tombs l. Pulm Pharmacol Ther. 2014 Oct;29(1):49-57. doi: 10.1016/j.pupt.2014.07.002. Epub 2014 Jul 12. Pulm Pharmacol Ther. 2014. PMID: 25020273 Clinical Trial.

9

Effect of severe renal impairment on umeclidinium and umeclidinium/vilanterol pharmacokinetics and safety: a single-blind, nonrandomized study.

Mehta R, Hardes K, Brealey N, Tombs L, Preece A, Kelleher D. Mehta R, et al. Among authors: tombs l. Int J Chron Obstruct Pulmon Dis. 2014 Dec 18;10:15-23. doi: 10.2147/COPD.S68094. eCollection 2015. Int J Chron Obstruct Pulmon Dis. 2014. PMID: 25565796 Free PMC article. Clinical Trial.

10

Prevention of clinically important deteriorations in COPD with umeclidinium/vilanterol.

Singh D, Maleki-Yazdi MR, Tombs L, Iqbal A, Fahy WA, Naya I. Singh D, et al. Among authors: tombs l. Int J Chron Obstruct Pulmon Dis. 2016 Jun 24;11:1413-24. doi: 10.2147/COPD.S101612. eCollection 2016. Int J Chron Obstruct Pulmon Dis. 2016. PMID: 27445468 Free PMC article.

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