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SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.
Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. Shaik S, et al. Among authors: fukushima h. J Exp Med. 2012 Jul 2;209(7):1289-307. doi: 10.1084/jem.20112446. Epub 2012 Jun 18. J Exp Med. 2012. PMID: 22711876 Free PMC article.
The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.
Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W. Shimizu K, et al. Among authors: fukushima h. Sci Signal. 2017 Jan 3;10(460):eaah4117. doi: 10.1126/scisignal.aah4117. Sci Signal. 2017. PMID: 28049764 Free PMC article.
Mcl-1 ubiquitination and destruction.
Inuzuka H, Fukushima H, Shaik S, Liu P, Lau AW, Wei W. Inuzuka H, et al. Among authors: fukushima h. Oncotarget. 2011 Mar;2(3):239-44. doi: 10.18632/oncotarget.242. Oncotarget. 2011. PMID: 21608150 Free PMC article. Review.
1,301 results