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Vascular endothelial growth factor A (VEGFA) gene polymorphisms have an impact on survival in a subgroup of indolent patients with chronic lymphocytic leukemia.
Lozano-Santos C, Martinez-Velasquez J, Fernandez-Cuevas B, Polo N, Navarro B, Millan I, Garcia JM, Collado R, Sanchez-Godoy P, Carbonell F, Garcia-Vela JA, Garcia-Marco JA, Gomez-Lozano N. Lozano-Santos C, et al. PLoS One. 2014 Jun 27;9(6):e101063. doi: 10.1371/journal.pone.0101063. eCollection 2014. PLoS One. 2014. PMID: 24971577 Free PMC article.
Biallelic ATM alterations detected at diagnosis identify a subset of treatment-naïve chronic lymphocytic leukemia patients with reduced overall survival similar to patients with p53 deletion.
Lozano-Santos C, García-Vela JA, Pérez-Sanz N, Nova-Gurumeta S, Fernandez-Cuevas B, Gomez-Lozano N, Sánchez-Beato M, Sanchez-Godoy P, Bueno JL, Garcia-Marco JA. Lozano-Santos C, et al. Leuk Lymphoma. 2017 Apr;58(4):859-865. doi: 10.1080/10428194.2016.1213829. Epub 2016 Aug 8. Leuk Lymphoma. 2017. PMID: 27499002
Arsenic trioxide synergistically potentiates the cytotoxic effect of fludarabine in chronic lymphocytic leukemia cells by further inactivating the Akt and ERK signaling pathways.
Lozano-Santos C, Amigo-Jiménez I, Nova-Gurumeta S, Pérez-Sanz N, García-Pardo A, García-Marco JA. Lozano-Santos C, et al. Biochem Biophys Res Commun. 2015 May 29;461(2):243-8. doi: 10.1016/j.bbrc.2015.04.007. Epub 2015 Apr 11. Biochem Biophys Res Commun. 2015. PMID: 25869069