Holtzman DM - Search Results

1

Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.

Pankiewicz JE, Guridi M, Kim J, Asuni AA, Sanchez S, Sullivan PM, Holtzman DM, Sadowski MJ. Pankiewicz JE, et al. Among authors: holtzman dm. Acta Neuropathol Commun. 2014 Jun 28;2:75. doi: 10.1186/s40478-014-0075-0. Acta Neuropathol Commun. 2014. PMID: 24972680 Free PMC article.

2

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice.

DeMattos RB, Brendza RP, Heuser JE, Kierson M, Cirrito JR, Fryer J, Sullivan PM, Fagan AM, Han X, Holtzman DM. DeMattos RB, et al. Among authors: holtzman dm. Neurochem Int. 2001 Nov-Dec;39(5-6):415-25. doi: 10.1016/s0197-0186(01)00049-3. Neurochem Int. 2001. PMID: 11578777

3

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T. Sadowski M, et al. Among authors: holtzman dm. Am J Pathol. 2004 Sep;165(3):937-48. doi: 10.1016/s0002-9440(10)63355-x. Am J Pathol. 2004. PMID: 15331417 Free PMC article.

4

Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM. Fryer JD, et al. Among authors: holtzman dm. J Neurosci. 2005 Mar 16;25(11):2803-10. doi: 10.1523/JNEUROSCI.5170-04.2005. J Neurosci. 2005. PMID: 15772340 Free PMC article.

5

Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta.

Morikawa M, Fryer JD, Sullivan PM, Christopher EA, Wahrle SE, DeMattos RB, O'Dell MA, Fagan AM, Lashuel HA, Walz T, Asai K, Holtzman DM. Morikawa M, et al. Among authors: holtzman dm. Neurobiol Dis. 2005 Jun-Jul;19(1-2):66-76. doi: 10.1016/j.nbd.2004.11.005. Neurobiol Dis. 2005. PMID: 15837562

6

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.

Fryer JD, Demattos RB, McCormick LM, O'Dell MA, Spinner ML, Bales KR, Paul SM, Sullivan PM, Parsadanian M, Bu G, Holtzman DM. Fryer JD, et al. Among authors: holtzman dm. J Biol Chem. 2005 Jul 8;280(27):25754-9. doi: 10.1074/jbc.M502143200. Epub 2005 May 11. J Biol Chem. 2005. PMID: 15888448 Free article.

7

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM. Wahrle SE, et al. Among authors: holtzman dm. J Clin Invest. 2008 Feb;118(2):671-82. doi: 10.1172/JCI33622. J Clin Invest. 2008. PMID: 18202749 Free PMC article.

8

The role of apolipoprotein E in Alzheimer's disease.

Kim J, Basak JM, Holtzman DM. Kim J, et al. Among authors: holtzman dm. Neuron. 2009 Aug 13;63(3):287-303. doi: 10.1016/j.neuron.2009.06.026. Neuron. 2009. PMID: 19679070 Free PMC article. Review.

9

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM. Kim J, et al. Among authors: holtzman dm. Neuron. 2009 Dec 10;64(5):632-44. doi: 10.1016/j.neuron.2009.11.013. Neuron. 2009. PMID: 20005821 Free PMC article.

10

Medicine. Prion-like behavior of amyloid-beta.

Kim J, Holtzman DM. Kim J, et al. Among authors: holtzman dm. Science. 2010 Nov 12;330(6006):918-9. doi: 10.1126/science.1198314. Science. 2010. PMID: 21071652 No abstract available.

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