Lehtio L - Search Results

1

Tankyrases: structure, function and therapeutic implications in cancer.

Haikarainen T, Krauss S, Lehtio L. Haikarainen T, et al. Among authors: lehtio l. Curr Pharm Des. 2014;20(41):6472-88. doi: 10.2174/1381612820666140630101525. Curr Pharm Des. 2014. PMID: 24975604 Free PMC article. Review.

2

Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite.

Vilchez Larrea SC, Haikarainen T, Narwal M, Schlesinger M, Venkannagari H, Flawiá MM, Villamil SH, Lehtiö L. Vilchez Larrea SC, et al. Among authors: lehtio l. PLoS One. 2012;7(9):e46063. doi: 10.1371/journal.pone.0046063. Epub 2012 Sep 25. PLoS One. 2012. PMID: 23049934 Free PMC article.

3

Screening and structural analysis of flavones inhibiting tankyrases.

Narwal M, Haikarainen T, Fallarero A, Vuorela PM, Lehtiö L. Narwal M, et al. Among authors: lehtio l. J Med Chem. 2013 May 9;56(9):3507-17. doi: 10.1021/jm3018783. Epub 2013 Apr 24. J Med Chem. 2013. PMID: 23574272

4

Tankyrases as drug targets.

Lehtiö L, Chi NW, Krauss S. Lehtiö L, et al. FEBS J. 2013 Aug;280(15):3576-93. doi: 10.1111/febs.12320. Epub 2013 Jun 18. FEBS J. 2013. PMID: 23648170 Free article. Review.

5

Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4.

Haikarainen T, Venkannagari H, Narwal M, Obaji E, Lee HW, Nkizinkiko Y, Lehtiö L. Haikarainen T, et al. Among authors: lehtio l. PLoS One. 2013 Jun 6;8(6):e65404. doi: 10.1371/journal.pone.0065404. Print 2013. PLoS One. 2013. PMID: 23762361 Free PMC article.

6

Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.

Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtiö L. Narwal M, et al. Among authors: lehtio l. J Med Chem. 2013 Oct 24;56(20):7880-9. doi: 10.1021/jm401463y. Epub 2013 Oct 11. J Med Chem. 2013. PMID: 24116873

7

para-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors.

Haikarainen T, Koivunen J, Narwal M, Venkannagari H, Obaji E, Joensuu P, Pihlajaniemi T, Lehtiö L. Haikarainen T, et al. Among authors: lehtio l. ChemMedChem. 2013 Dec;8(12):1978-85. doi: 10.1002/cmdc.201300337. Epub 2013 Oct 15. ChemMedChem. 2013. PMID: 24130191

8

Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors.

Haikarainen T, Narwal M, Joensuu P, Lehtiö L. Haikarainen T, et al. Among authors: lehtio l. ACS Med Chem Lett. 2013 Nov 20;5(1):18-22. doi: 10.1021/ml400292s. eCollection 2014 Jan 9. ACS Med Chem Lett. 2013. PMID: 24900770 Free PMC article.

9

Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases.

Kumpan K, Nathubhai A, Zhang C, Wood PJ, Lloyd MD, Thompson AS, Haikarainen T, Lehtiö L, Threadgill MD. Kumpan K, et al. Among authors: lehtio l. Bioorg Med Chem. 2015 Jul 1;23(13):3013-32. doi: 10.1016/j.bmc.2015.05.005. Epub 2015 May 13. Bioorg Med Chem. 2015. PMID: 26026769

10

Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics.

Nkizinkiko Y, Suneel Kumar BVS, Jeankumar VU, Haikarainen T, Koivunen J, Madhuri C, Yogeeswari P, Venkannagari H, Obaji E, Pihlajaniemi T, Sriram D, Lehtiö L. Nkizinkiko Y, et al. Among authors: lehtio l. Bioorg Med Chem. 2015 Aug 1;23(15):4139-4149. doi: 10.1016/j.bmc.2015.06.063. Epub 2015 Jul 2. Bioorg Med Chem. 2015. PMID: 26183543

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