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Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.
de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M. de Opakua AI, et al. Among authors: nguyen lt. Nat Commun. 2017 May 18;8:15163. doi: 10.1038/ncomms15163. Nat Commun. 2017. PMID: 28516903 Free PMC article.
The Gαi-GIV binding interface is a druggable protein-protein interaction.
DiGiacomo V, de Opakua AI, Papakonstantinou MP, Nguyen LT, Merino N, Blanco-Canosa JB, Blanco FJ, Garcia-Marcos M. DiGiacomo V, et al. Among authors: nguyen lt. Sci Rep. 2017 Aug 17;7(1):8575. doi: 10.1038/s41598-017-08829-7. Sci Rep. 2017. PMID: 28819150 Free PMC article.
1,198 results