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Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor β.
Christmann RB, Mathes A, Affandi AJ, Padilla C, Nazari B, Bujor AM, Stifano G, Lafyatis R. Christmann RB, et al. Arthritis Rheum. 2013 May;65(5):1335-46. doi: 10.1002/art.37859. Arthritis Rheum. 2013. PMID: 23335246 Free PMC article.
miR-155 in the progression of lung fibrosis in systemic sclerosis.
Christmann RB, Wooten A, Sampaio-Barros P, Borges CL, Carvalho CR, Kairalla RA, Feghali-Bostwick C, Ziemek J, Mei Y, Goummih S, Tan J, Alvarez D, Kass DJ, Rojas M, de Mattos TL, Parra E, Stifano G, Capelozzi VL, Simms RW, Lafyatis R. Christmann RB, et al. Arthritis Res Ther. 2016 Jul 5;18(1):155. doi: 10.1186/s13075-016-1054-6. Arthritis Res Ther. 2016. PMID: 27377409 Free PMC article.
Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients.
Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, Nakerakanti S, York M, Farina G, Whitfield ML, Spiera RF, Christmann RB, Gordon JK, Weinberg J, Simms RW, Lafyatis R. Rice LM, et al. Among authors: christmann rb. J Clin Invest. 2015 Jul 1;125(7):2795-807. doi: 10.1172/JCI77958. Epub 2015 Jun 22. J Clin Invest. 2015. PMID: 26098215 Free PMC article. Clinical Trial.
28 results