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Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q. Zheng X, et al. Among authors: chen z, chen x. Genes Dev. 2014 Jul 1;28(13):1429-44. doi: 10.1101/gad.242131.114. Genes Dev. 2014. PMID: 24990963 Free PMC article.
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG Jr, Baldwin AS, Zhang Q. Zhang J, et al. Among authors: chen x. Science. 2018 Jul 20;361(6399):290-295. doi: 10.1126/science.aap8411. Science. 2018. PMID: 30026228 Free PMC article.
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.
Zurlo G, Liu X, Takada M, Fan C, Simon JM, Ptacek TS, Rodriguez J, von Kriegsheim A, Liu J, Locasale JW, Robinson A, Zhang J, Holler JM, Kim B, Zikánová M, Bierau J, Xie L, Chen X, Li M, Perou CM, Zhang Q. Zurlo G, et al. Among authors: chen x. Nat Commun. 2019 Nov 15;10(1):5177. doi: 10.1038/s41467-019-13168-4. Nat Commun. 2019. PMID: 31729379 Free PMC article.
TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss.
Hu L, Xie H, Liu X, Potjewyd F, James LI, Wilkerson EM, Herring LE, Xie L, Chen X, Cabrera JC, Hong K, Liao C, Tan X, Baldwin AS, Gong K, Zhang Q. Hu L, et al. Among authors: chen x. Cancer Discov. 2020 Mar;10(3):460-475. doi: 10.1158/2159-8290.CD-19-0837. Epub 2019 Dec 6. Cancer Discov. 2020. PMID: 31810986 Free PMC article.
TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors.
Liu J, Yu X, Chen H, Kaniskan HÜ, Xie L, Chen X, Jin J, Wei W. Liu J, et al. Among authors: chen h, chen x. J Am Chem Soc. 2022 Jul 20;144(28):12934-12941. doi: 10.1021/jacs.2c04824. Epub 2022 Jul 5. J Am Chem Soc. 2022. PMID: 35786952 Free PMC article.
Redox regulation of Rac1 by thiol oxidation.
Hobbs GA, Mitchell LE, Arrington ME, Gunawardena HP, DeCristo MJ, Loeser RF, Chen X, Cox AD, Campbell SL. Hobbs GA, et al. Among authors: chen x. Free Radic Biol Med. 2015 Feb;79:237-50. doi: 10.1016/j.freeradbiomed.2014.09.027. Epub 2014 Oct 5. Free Radic Biol Med. 2015. PMID: 25289457 Free PMC article.
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