Aronchik I - Search Results

1

The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.

Aronchik I, Kundu A, Quirit JG, Firestone GL. Aronchik I, et al. Mol Cancer Res. 2014 Nov;12(11):1621-1634. doi: 10.1158/1541-7786.MCR-14-0018. Epub 2014 Jul 9. Mol Cancer Res. 2014. PMID: 25009292 Free PMC article.

2

Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells.

Brew CT, Aronchik I, Hsu JC, Sheen JH, Dickson RB, Bjeldanes LF, Firestone GL. Brew CT, et al. Among authors: aronchik i. Int J Cancer. 2006 Feb 15;118(4):857-68. doi: 10.1002/ijc.21445. Int J Cancer. 2006. PMID: 16152627

3

The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.

Nguyen HH, Aronchik I, Brar GA, Nguyen DH, Bjeldanes LF, Firestone GL. Nguyen HH, et al. Among authors: aronchik i. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19750-5. doi: 10.1073/pnas.0806581105. Epub 2008 Dec 8. Proc Natl Acad Sci U S A. 2008. PMID: 19064917 Free PMC article.

4

Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity.

Brew CT, Aronchik I, Kosco K, McCammon J, Bjeldanes LF, Firestone GL. Brew CT, et al. Among authors: aronchik i. Int J Cancer. 2009 May 15;124(10):2294-302. doi: 10.1002/ijc.24210. Int J Cancer. 2009. PMID: 19173291 Free PMC article.

5

Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.

Aronchik I, Bjeldanes LF, Firestone GL. Aronchik I, et al. Cancer Res. 2010 Jun 15;70(12):4961-71. doi: 10.1158/0008-5472.CAN-09-3349. Epub 2010 Jun 8. Cancer Res. 2010. PMID: 20530686

6

Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.

Aronchik I, Chen T, Durkin KA, Horwitz MS, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL. Aronchik I, et al. Mol Carcinog. 2012 Nov;51(11):881-94. doi: 10.1002/mc.20857. Epub 2011 Oct 19. Mol Carcinog. 2012. PMID: 22012859

7

Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.

Poindexter KM, Matthew S, Aronchik I, Firestone GL. Poindexter KM, et al. Among authors: aronchik i. Cell Biol Toxicol. 2016 Apr;32(2):103-19. doi: 10.1007/s10565-016-9321-5. Epub 2016 Apr 7. Cell Biol Toxicol. 2016. PMID: 27055402 Free PMC article.

8

Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.

Quirit JG, Lavrenov SN, Poindexter K, Xu J, Kyauk C, Durkin KA, Aronchik I, Tomasiak T, Solomatin YA, Preobrazhenskaya MN, Firestone GL. Quirit JG, et al. Among authors: aronchik i. Biochem Pharmacol. 2017 Mar 1;127:13-27. doi: 10.1016/j.bcp.2016.12.007. Epub 2016 Dec 12. Biochem Pharmacol. 2017. PMID: 27979631

9

DEVD-NucView488: a novel class of enzyme substrates for real-time detection of caspase-3 activity in live cells.

Cen H, Mao F, Aronchik I, Fuentes RJ, Firestone GL. Cen H, et al. Among authors: aronchik i. FASEB J. 2008 Jul;22(7):2243-52. doi: 10.1096/fj.07-099234. Epub 2008 Feb 8. FASEB J. 2008. PMID: 18263700

10

Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance.

Aronchik I, Dai Y, Labenski M, Barnes C, Jones T, Qiao L, Beebe L, Malek M, Elis W, Shi T, Mavrommatis K, Bray GL, Filvaroff EH. Aronchik I, et al. Mol Cancer Res. 2019 Feb;17(2):642-654. doi: 10.1158/1541-7786.MCR-17-0554. Epub 2018 Oct 1. Mol Cancer Res. 2019. PMID: 30275173 Free article.

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