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CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.
Waters JD, Sanchez C, Sahin A, Futalan D, Gonda DD, Scheer JK, Akers J, Palanichamy K, Waterman P, Chakravarti A, Weissleder R, Morse B, Marsh N, Furfine E, Chen CC, Carvajal I, Carter BS. Waters JD, et al. Among authors: chen cc. J Neurooncol. 2012 Oct;110(1):37-48. doi: 10.1007/s11060-012-0948-7. Epub 2012 Aug 9. J Neurooncol. 2012. PMID: 22875706 Free PMC article.
RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas.
Bao ZS, Chen HM, Yang MY, Zhang CB, Yu K, Ye WL, Hu BQ, Yan W, Zhang W, Akers J, Ramakrishnan V, Li J, Carter B, Liu YW, Hu HM, Wang Z, Li MY, Yao K, Qiu XG, Kang CS, You YP, Fan XL, Song WS, Li RQ, Su XD, Chen CC, Jiang T. Bao ZS, et al. Among authors: chen cc, chen hm. Genome Res. 2014 Nov;24(11):1765-73. doi: 10.1101/gr.165126.113. Epub 2014 Aug 18. Genome Res. 2014. PMID: 25135958 Free PMC article.
Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas.
Li J, Taich ZJ, Goyal A, Gonda D, Akers J, Adhikari B, Patel K, Vandenberg S, Yan W, Bao Z, Carter BS, Wang R, Mao Y, Jiang T, Chen CC. Li J, et al. Among authors: chen cc. Oncotarget. 2014 Sep 15;5(17):7342-56. doi: 10.18632/oncotarget.2350. Oncotarget. 2014. PMID: 25277177 Free PMC article.
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