Lu J - Search Results

1

FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels.

Chen L, Luo LF, Lu J, Li L, Liu YF, Wang J, Liu H, Song H, Jiang H, Chen SJ, Luo C, Li KK. Chen L, et al. Among authors: lu j. PLoS One. 2014 Jul 22;9(7):e103033. doi: 10.1371/journal.pone.0103033. eCollection 2014. PLoS One. 2014. PMID: 25050888 Free PMC article.

2

Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study.

Kong X, Ouyang S, Liang Z, Lu J, Chen L, Shen B, Li D, Zheng M, Li KK, Luo C, Jiang H. Kong X, et al. Among authors: lu j. PLoS One. 2011;6(9):e25444. doi: 10.1371/journal.pone.0025444. Epub 2011 Sep 30. PLoS One. 2011. PMID: 21984927 Free PMC article.

3

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.

Lu J, Zeng H, Liang Z, Chen L, Zhang L, Zhang H, Liu H, Jiang H, Shen B, Huang M, Geng M, Spiegel S, Luo C. Lu J, et al. Sci Rep. 2015 Oct 8;5:14739. doi: 10.1038/srep14739. Sci Rep. 2015. PMID: 26446703 Free PMC article.

4

A Sphingosine-1-Phosphate Modulator Ameliorates Polycystic Kidney Disease in Han:SPRD Rats.

Li X, Wu M, Chen L, Lu J, Li G, Fu L, Qi N, Lin Y, Sun Z, Wang X, Zhang H, Liu J, Jiang H, Li L, Mei CL, Luo C. Li X, et al. Among authors: lu j. Am J Nephrol. 2020;51(1):1-10. doi: 10.1159/000502855. Epub 2019 Nov 6. Am J Nephrol. 2020. PMID: 31694015

5

Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer.

Gao F, Chen X, Lu J, Hu S, Xu H, Shi Y, Feng M, Ding J, Liu H, Luo C, Xie Z, Wang J. Gao F, et al. Among authors: lu j. Eur J Med Chem. 2021 Apr 5;215:113274. doi: 10.1016/j.ejmech.2021.113274. Epub 2021 Feb 7. Eur J Med Chem. 2021. PMID: 33592537

6

Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization.

Kong X, Qin J, Li Z, Vultur A, Tong L, Feng E, Rajan G, Liu S, Lu J, Liang Z, Zheng M, Zhu W, Jiang H, Herlyn M, Liu H, Marmorstein R, Luo C. Kong X, et al. Among authors: lu j. Org Biomol Chem. 2012 Sep 28;10(36):7402-17. doi: 10.1039/c2ob26081f. Org Biomol Chem. 2012. PMID: 22875039 Free PMC article.

7

Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.

Kong X, Chen L, Jiao L, Jiang X, Lian F, Lu J, Zhu K, Du D, Liu J, Ding H, Zhang N, Shen J, Zheng M, Chen K, Liu X, Jiang H, Luo C. Kong X, et al. Among authors: lu j. J Med Chem. 2014 Nov 26;57(22):9512-21. doi: 10.1021/jm501230c. Epub 2014 Nov 12. J Med Chem. 2014. PMID: 25369470

8

Computational drug discovery.

Ou-Yang SS, Lu JY, Kong XQ, Liang ZJ, Luo C, Jiang H. Ou-Yang SS, et al. Acta Pharmacol Sin. 2012 Sep;33(9):1131-40. doi: 10.1038/aps.2012.109. Epub 2012 Aug 27. Acta Pharmacol Sin. 2012. PMID: 22922346 Free PMC article. Review.

9

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.

Hait NC, Wise LE, Allegood JC, O'Brien M, Avni D, Reeves TM, Knapp PE, Lu J, Luo C, Miles MF, Milstien S, Lichtman AH, Spiegel S. Hait NC, et al. Among authors: lu j. Nat Neurosci. 2014 Jul;17(7):971-80. doi: 10.1038/nn.3728. Epub 2014 May 25. Nat Neurosci. 2014. PMID: 24859201 Free PMC article.

10

Targeting epigenetics in nervous system disease.

Zhang R, Lu J, Kong X, Jin L, Luo C. Zhang R, et al. Among authors: lu j. CNS Neurol Disord Drug Targets. 2013 Feb 1;12(1):126-41. doi: 10.2174/1871527311312010018. CNS Neurol Disord Drug Targets. 2013. PMID: 23244434 Review.

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