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Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
Blanco S, Dietmann S, Flores JV, Hussain S, Kutter C, Humphreys P, Lukk M, Lombard P, Treps L, Popis M, Kellner S, Hölter SM, Garrett L, Wurst W, Becker L, Klopstock T, Fuchs H, Gailus-Durner V, Hrabĕ de Angelis M, Káradóttir RT, Helm M, Ule J, Gleeson JG, Odom DT, Frye M. Blanco S, et al. Among authors: ule j. EMBO J. 2014 Sep 17;33(18):2020-39. doi: 10.15252/embj.201489282. Epub 2014 Jul 25. EMBO J. 2014. PMID: 25063673 Free PMC article.
N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast.
Varier RA, Sideri T, Capitanchik C, Manova Z, Calvani E, Rossi A, Edupuganti RR, Ensinck I, Chan VWC, Patel H, Kirkpatrick J, Faull P, Snijders AP, Vermeulen M, Ralser M, Ule J, Luscombe NM, van Werven FJ. Varier RA, et al. Among authors: ule j. Elife. 2022 Nov 24;11:e84034. doi: 10.7554/eLife.84034. Elife. 2022. PMID: 36422864 Free PMC article.
The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes.
Barreiro RAS, Guardia GDA, Meliso FM, Lei X, Li WQ, Savio A, Fellermeyer M, Conceição HB, Mercuri RLV, Landry T, Qiao M, Blazquez L, Ule J, Penalva LOF, Galante PAF. Barreiro RAS, et al. Among authors: ule j. RNA Biol. 2023 Jan;20(1):311-322. doi: 10.1080/15476286.2023.2221511. RNA Biol. 2023. PMID: 37294214 Free PMC article.
No way out: when RNA elements promote nuclear retention.
Agostini F, Ule J, Zagalak JA. Agostini F, et al. Among authors: ule j. EMBO J. 2018 Mar 15;37(6):e99123. doi: 10.15252/embj.201899123. Epub 2018 Feb 27. EMBO J. 2018. PMID: 29487065 Free PMC article.
171 results