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Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats.
Chettimada S, Joshi SR, Alzoubi A, Gebb SA, McMurtry IF, Gupte R, Gupte SA. Chettimada S, et al. Among authors: joshi sr. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L545-56. doi: 10.1152/ajplung.00303.2013. Epub 2014 Jul 25. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 25063801 Free PMC article.
Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.
Hashimoto R, Joshi SR, Jiang H, Capdevila JH, McMurtry IF, Laniado Schwartzman M, Gupte SA. Hashimoto R, et al. Among authors: joshi sr. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H293-H303. doi: 10.1152/ajpheart.00785.2016. Epub 2017 May 26. Am J Physiol Heart Circ Physiol. 2017. PMID: 28550179 Free PMC article.
Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation.
Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell I, Leopold J, Hu CJ, McMurtry IF, D'Alessandro A, Stenmark KR, Gupte SA. Joshi SR, et al. Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L773-L786. doi: 10.1152/ajplung.00001.2020. Epub 2020 Mar 11. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32159369 Free PMC article.
Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension.
Hashimoto R, Lanier GM, Dhagia V, Joshi SR, Jordan A, Waddell I, Tuder R, Stenmark KR, Wolin MS, McMurtry IF, Gupte SA. Hashimoto R, et al. Among authors: joshi sr. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L386-L401. doi: 10.1152/ajplung.00327.2019. Epub 2020 Jan 8. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31913656 Free PMC article.
20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.
Lakhkar A, Dhagia V, Joshi SR, Gotlinger K, Patel D, Sun D, Wolin MS, Schwartzman ML, Gupte SA. Lakhkar A, et al. Among authors: joshi sr. Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1107-17. doi: 10.1152/ajpheart.00961.2015. Epub 2016 Feb 26. Am J Physiol Heart Circ Physiol. 2016. PMID: 26921441 Free PMC article.
Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency.
Chettimada S, Joshi SR, Dhagia V, Aiezza A 2nd, Lincoln TM, Gupte R, Miano JM, Gupte SA. Chettimada S, et al. Among authors: joshi sr. Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H904-H912. doi: 10.1152/ajpheart.00335.2016. Epub 2016 Aug 12. Am J Physiol Heart Circ Physiol. 2016. PMID: 27521420 Free PMC article.
497 results