Klint JK - Search Results

1

From foe to friend: using animal toxins to investigate ion channel function.

Kalia J, Milescu M, Salvatierra J, Wagner J, Klint JK, King GF, Olivera BM, Bosmans F. Kalia J, et al. Among authors: klint jk. J Mol Biol. 2015 Jan 16;427(1):158-175. doi: 10.1016/j.jmb.2014.07.027. Epub 2014 Aug 1. J Mol Biol. 2015. PMID: 25088688 Free PMC article. Review.

2

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.

Klint JK, Senff S, Rupasinghe DB, Er SY, Herzig V, Nicholson GM, King GF. Klint JK, et al. Toxicon. 2012 Sep 15;60(4):478-91. doi: 10.1016/j.toxicon.2012.04.337. Epub 2012 Apr 20. Toxicon. 2012. PMID: 22543187 Review.

3

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF. Klint JK, et al. Br J Pharmacol. 2015 May;172(10):2445-58. doi: 10.1111/bph.13081. Epub 2015 Mar 4. Br J Pharmacol. 2015. PMID: 25754331 Free PMC article.

4

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

Klint JK, Senff S, Saez NJ, Seshadri R, Lau HY, Bende NS, Undheim EA, Rash LD, Mobli M, King GF. Klint JK, et al. PLoS One. 2013 May 7;8(5):e63865. doi: 10.1371/journal.pone.0063865. Print 2013. PLoS One. 2013. PMID: 23667680 Free PMC article.

5

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels.

Klint JK, Berecki G, Durek T, Mobli M, Knapp O, King GF, Adams DJ, Alewood PF, Rash LD. Klint JK, et al. Biochem Pharmacol. 2014 May 15;89(2):276-86. doi: 10.1016/j.bcp.2014.02.008. Epub 2014 Feb 19. Biochem Pharmacol. 2014. PMID: 24561180

6

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.

Yang S, Xiao Y, Kang D, Liu J, Li Y, Undheim EA, Klint JK, Rong M, Lai R, King GF. Yang S, et al. Among authors: klint jk. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17534-9. doi: 10.1073/pnas.1306285110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082113 Free PMC article.

7

Fluorescence labeling of a Na_V1.7-targeted peptide for near-infrared nerve visualization.

Gonzales J, Pirovano G, Chow CY, de Souza Franca PD, Carter LM, Klint JK, Guru N, Lewis JS, King GF, Reiner T. Gonzales J, et al. Among authors: klint jk. EJNMMI Res. 2020 May 14;10(1):49. doi: 10.1186/s13550-020-00630-4. EJNMMI Res. 2020. PMID: 32409881 Free PMC article.

8

Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7.

Klint JK, Chin YK, Mobli M. Klint JK, et al. Mol Pharmacol. 2015 Dec;88(6):1002-10. doi: 10.1124/mol.115.100784. Epub 2015 Oct 1. Mol Pharmacol. 2015. PMID: 26429937

9

Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators.

Botte M, Huber S, Bucher D, Klint JK, Rodríguez D, Tagmose L, Chami M, Cheng R, Hennig M, Abdul Rahman W. Botte M, et al. Among authors: klint jk. PNAS Nexus. 2022 Jun 16;1(3):pgac083. doi: 10.1093/pnasnexus/pgac083. eCollection 2022 Jul. PNAS Nexus. 2022. PMID: 36741467 Free PMC article.

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