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A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits.
Anil TM, Dandu A, Harsha K, Singh J, Shree N, Kumar VS, Lakshmi MN, Sunil V, Harish C, Balamurali GV, Naveen Kumar BS, Gopala AS, Pratibha S, Sadasivuni M, Anup MO, Moolemath Y, Venkataranganna MV, Jagannath MR, Somesh BP. Anil TM, et al. Among authors: balamurali gv. BMC Pharmacol Toxicol. 2014 Aug 7;15:43. doi: 10.1186/2050-6511-15-43. BMC Pharmacol Toxicol. 2014. PMID: 25098735 Free PMC article.
CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models.
Anil TM, Harish C, Lakshmi MN, Harsha K, Onkaramurthy M, Sathish Kumar V, Shree N, Geetha V, Balamurali GV, Gopala AS, Madhusudhan Reddy B, Govind MK, Anup MO, Moolemath Y, Venkataranganna MV, Jagannath MR, Somesh BP. Anil TM, et al. Among authors: balamurali gv. Cardiovasc Diabetol. 2014 Jan 25;13:27. doi: 10.1186/1475-2840-13-27. Cardiovasc Diabetol. 2014. PMID: 24460834 Free PMC article.