Mamidi RN - Search Results

1

Carbohydrate malabsorption mechanism for tumor formation in rats treated with the SGLT2 inhibitor canagliflozin.

Mamidi RN, Proctor J, De Jonghe S, Feyen B, Moesen E, Vinken P, Ma JY, Bryant S, Snook S, Louden C, Lammens G, Ways K, Kelley MF, Johnson MD. Mamidi RN, et al. Chem Biol Interact. 2014 Sep 25;221:109-18. doi: 10.1016/j.cbi.2014.08.001. Epub 2014 Aug 14. Chem Biol Interact. 2014. PMID: 25130857

2

Carcinogenicity in rats of the SGLT2 inhibitor canagliflozin.

De Jonghe S, Proctor J, Vinken P, Feyen B, Wynant I, Marien D, Geys H, Mamidi RN, Johnson MD. De Jonghe S, et al. Among authors: mamidi rn. Chem Biol Interact. 2014 Dec 5;224:1-12. doi: 10.1016/j.cbi.2014.09.018. Epub 2014 Oct 5. Chem Biol Interact. 2014. PMID: 25289773

3

Successful integration of nonclinical and clinical findings in interpreting the clinical relevance of rodent neoplasia with a new chemical entity.

Ways K, Johnson MD, Mamidi RN, Proctor J, De Jonghe S, Louden C. Ways K, et al. Among authors: mamidi rn. Toxicol Pathol. 2015 Jan;43(1):48-56. doi: 10.1177/0192623314557179. Epub 2014 Nov 14. Toxicol Pathol. 2015. PMID: 25398756

4

Renal tubular and adrenal medullary tumors in the 2-year rat study with canagliflozin confirmed to be secondary to carbohydrate (glucose) malabsorption in the 15-month mechanistic rat study.

De Jonghe S, Johnson MD, Mamidi RNVS, Vinken P, Feyen B, Lammens G, Proctor J. De Jonghe S, et al. Among authors: mamidi rnvs. Chem Biol Interact. 2017 Nov 1;277:85-90. doi: 10.1016/j.cbi.2017.09.008. Epub 2017 Sep 12. Chem Biol Interact. 2017. PMID: 28916336

5

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

Mamidi RN, Cuyckens F, Chen J, Scheers E, Kalamaridis D, Lin R, Silva J, Sha S, Evans DC, Kelley MF, Devineni D, Johnson MD, Lim HK. Mamidi RN, et al. Drug Metab Dispos. 2014 May;42(5):903-16. doi: 10.1124/dmd.113.056440. Epub 2014 Feb 25. Drug Metab Dispos. 2014. PMID: 24568888 Clinical Trial.

6

In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin.

Mamidi RNVS, Dallas S, Sensenhauser C, Lim HK, Scheers E, Verboven P, Cuyckens F, Leclercq L, Evans DC, Kelley MF, Johnson MD, Snoeys J. Mamidi RNVS, et al. Br J Clin Pharmacol. 2017 May;83(5):1082-1096. doi: 10.1111/bcp.13186. Epub 2016 Dec 20. Br J Clin Pharmacol. 2017. PMID: 27862160 Free PMC article.

7

Pharmacokinetics, efficacy and toxicity of different pegylated liposomal doxorubicin formulations in preclinical models: is a conventional bioequivalence approach sufficient to ensure therapeutic equivalence of pegylated liposomal doxorubicin products?

Mamidi RN, Weng S, Stellar S, Wang C, Yu N, Huang T, Tonelli AP, Kelley MF, Angiuoli A, Fung MC. Mamidi RN, et al. Cancer Chemother Pharmacol. 2010 Nov;66(6):1173-84. doi: 10.1007/s00280-010-1406-x. Epub 2010 Jul 27. Cancer Chemother Pharmacol. 2010. PMID: 20661737

8

Pharmacokinetics, metabolism, excretion and plasma protein binding of 14C-levofloxacin after a single oral administration in the Rhesus monkey.

Hemeryck A, Mamidi RN, Bottacini M, Macpherson D, Kao M, Kelley MF. Hemeryck A, et al. Among authors: mamidi rn. Xenobiotica. 2006 Jul;36(7):597-613. doi: 10.1080/00498250600674436. Xenobiotica. 2006. PMID: 16864506

9

Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs.

Mamidi RN, Mannens G, Annaert P, Hendrickx J, Goris I, Bockx M, Janssen CG, Kao M, Kelley MF, Meuldermans W. Mamidi RN, et al. Drug Metab Dispos. 2007 Apr;35(4):566-75. doi: 10.1124/dmd.106.012336. Epub 2007 Jan 12. Drug Metab Dispos. 2007. PMID: 17220243

10

In vitro metabolism of canagliflozin in human liver, kidney, intestine microsomes, and recombinant uridine diphosphate glucuronosyltransferases (UGT) and the effect of genetic variability of UGT enzymes on the pharmacokinetics of canagliflozin in humans.

Francke S, Mamidi RN, Solanki B, Scheers E, Jadwin A, Favis R, Devineni D. Francke S, et al. Among authors: mamidi rn. J Clin Pharmacol. 2015 Sep;55(9):1061-72. doi: 10.1002/jcph.506. Epub 2015 May 20. J Clin Pharmacol. 2015. PMID: 25827774

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