Nam KH - Search Results

1

Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.

Huo Y, Nam KH, Ding F, Lee H, Wu L, Xiao Y, Farchione MD Jr, Zhou S, Rajashankar K, Kurinov I, Zhang R, Ke A. Huo Y, et al. Among authors: nam kh. Nat Struct Mol Biol. 2014 Sep;21(9):771-7. doi: 10.1038/nsmb.2875. Epub 2014 Aug 17. Nat Struct Mol Biol. 2014. PMID: 25132177 Free PMC article.

2

Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli.

Perez-Rodriguez R, Haitjema C, Huang Q, Nam KH, Bernardis S, Ke A, DeLisa MP. Perez-Rodriguez R, et al. Among authors: nam kh. Mol Microbiol. 2011 Feb;79(3):584-99. doi: 10.1111/j.1365-2958.2010.07482.x. Epub 2010 Dec 13. Mol Microbiol. 2011. PMID: 21255106 Free PMC article.

3

Crystal structure of clustered regularly interspaced short palindromic repeats (CRISPR)-associated Csn2 protein revealed Ca2+-dependent double-stranded DNA binding activity.

Nam KH, Kurinov I, Ke A. Nam KH, et al. J Biol Chem. 2011 Sep 2;286(35):30759-30768. doi: 10.1074/jbc.M111.256263. Epub 2011 Jun 21. J Biol Chem. 2011. PMID: 21697083 Free PMC article.

4

Cas5d protein processes pre-crRNA and assembles into a cascade-like interference complex in subtype I-C/Dvulg CRISPR-Cas system.

Nam KH, Haitjema C, Liu X, Ding F, Wang H, DeLisa MP, Ke A. Nam KH, et al. Structure. 2012 Sep 5;20(9):1574-84. doi: 10.1016/j.str.2012.06.016. Epub 2012 Jul 26. Structure. 2012. PMID: 22841292 Free PMC article.

5

Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein.

Nam KH, Ding F, Haitjema C, Huang Q, DeLisa MP, Ke A. Nam KH, et al. J Biol Chem. 2012 Oct 19;287(43):35943-52. doi: 10.1074/jbc.M112.382598. Epub 2012 Aug 31. J Biol Chem. 2012. PMID: 22942283 Free PMC article.

6

Nucleic acid binding surface and dimer interface revealed by CRISPR-associated CasB protein structures.

Nam KH, Huang Q, Ke A. Nam KH, et al. FEBS Lett. 2012 Nov 16;586(22):3956-61. doi: 10.1016/j.febslet.2012.09.041. Epub 2012 Oct 16. FEBS Lett. 2012. PMID: 23079036 Free PMC article.

7

Characterizing Metal-Dependent Nucleases of CRISPR-Cas Prokaryotic Adaptive Immunity Systems.

Nam KH, DeLisa MP, Ke A. Nam KH, et al. Methods Mol Biol. 2015;1311:265-76. doi: 10.1007/978-1-4939-2687-9_17. Methods Mol Biol. 2015. PMID: 25981479

8

How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.

Xiao Y, Ng S, Nam KH, Ke A. Xiao Y, et al. Among authors: nam kh. Nature. 2017 Oct 5;550(7674):137-141. doi: 10.1038/nature24020. Epub 2017 Sep 4. Nature. 2017. PMID: 28869593 Free PMC article.

9

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.

Hu C, Almendros C, Nam KH, Costa AR, Vink JNA, Haagsma AC, Bagde SR, Brouns SJJ, Ke A. Hu C, et al. Among authors: nam kh. Nature. 2021 Oct;598(7881):515-520. doi: 10.1038/s41586-021-03951-z. Epub 2021 Sep 29. Nature. 2021. PMID: 34588691 Free PMC article.

10

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.

Hu C, Ni D, Nam KH, Majumdar S, McLean J, Stahlberg H, Terns MP, Ke A. Hu C, et al. Among authors: nam kh. Mol Cell. 2022 Aug 4;82(15):2754-2768.e5. doi: 10.1016/j.molcel.2022.06.007. Epub 2022 Jul 13. Mol Cell. 2022. PMID: 35835111 Free PMC article.

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