Young IG - Search Results

1

Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation.

Carr PD, Ewens CL, Dai J, Ollis DL, Murphy JM, Jackson CJ, Young IG. Carr PD, et al. Among authors: young ig. Biochem J. 2014 Nov 1;463(3):393-403. doi: 10.1042/BJ20140863. Biochem J. 2014. PMID: 25137390

2

A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5.

Murphy JM, Ford SC, Wiedemann UM, Carr PD, Ollis DL, Young IG. Murphy JM, et al. Among authors: young ig. J Biol Chem. 2003 Mar 21;278(12):10572-7. doi: 10.1074/jbc.M211664200. Epub 2003 Jan 12. J Biol Chem. 2003. PMID: 12525483 Free article.

3

Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.

Murphy JM, Ford SC, Olsen JE, Gustin SE, Jeffrey PD, Ollis DL, Young IG. Murphy JM, et al. Among authors: young ig. J Biol Chem. 2004 Jun 18;279(25):26500-8. doi: 10.1074/jbc.M402705200. Epub 2004 Apr 1. J Biol Chem. 2004. PMID: 15060062 Free article.

4

IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor.

Murphy JM, Young IG. Murphy JM, et al. Among authors: young ig. Vitam Horm. 2006;74:1-30. doi: 10.1016/S0083-6729(06)74001-8. Vitam Horm. 2006. PMID: 17027509 Review.

5

The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation.

Mirza S, Walker A, Chen J, Murphy JM, Young IG. Mirza S, et al. Among authors: young ig. Biochem J. 2010 Feb 24;426(3):307-17. doi: 10.1042/BJ20091745. Biochem J. 2010. PMID: 20078425

6

Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.

Mirza S, Chen J, Wen B, Ewens CL, Dai J, Murphy JM, Young IG. Mirza S, et al. Among authors: young ig. J Biol Chem. 2010 Jul 16;285(29):22370-81. doi: 10.1074/jbc.M110.117465. Epub 2010 May 14. J Biol Chem. 2010. PMID: 20472554 Free PMC article.

7

Clarification of the role of N-glycans on the common beta-subunit of the human IL-3, IL-5 and GM-CSF receptors and the murine IL-3 beta-receptor in ligand-binding and receptor activation.

Murphy JM, Soboleva TA, Mirza S, Ford SC, Olsen JE, Chen J, Young IG. Murphy JM, et al. Among authors: young ig. Cytokine. 2008 May;42(2):234-242. doi: 10.1016/j.cyto.2008.02.010. Epub 2008 Apr 18. Cytokine. 2008. PMID: 18374598

8

A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode.

Chen J, Olsen J, Ford S, Mirza S, Walker A, Murphy JM, Young IG. Chen J, et al. Among authors: young ig. J Biol Chem. 2009 Feb 27;284(9):5763-73. doi: 10.1074/jbc.M808197200. Epub 2008 Dec 24. J Biol Chem. 2009. PMID: 19109256 Free article.

9

The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.

Mirza S, Chen J, Murphy JM, Young IG. Mirza S, et al. Among authors: young ig. J Biol Chem. 2010 Aug 6;285(32):24759-68. doi: 10.1074/jbc.M109.097881. Epub 2010 Jun 1. J Biol Chem. 2010. PMID: 20516062 Free PMC article.

10

Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution.

Yao S, Young IG, Norton RS, Murphy JM. Yao S, et al. Among authors: young ig. Biochemistry. 2011 Apr 5;50(13):2464-77. doi: 10.1021/bi101810f. Epub 2011 Mar 2. Biochemistry. 2011. PMID: 21329364

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