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Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis.
Tannour-Louet M, York B, Tang K, Stashi E, Bouguerra H, Zhou S, Yu H, Wong LJ, Stevens RD, Xu J, Newgard CB, O'Malley BW, Louet JF. Tannour-Louet M, et al. Among authors: zhou s. Mol Endocrinol. 2014 Oct;28(10):1707-18. doi: 10.1210/me.2014-1083. Epub 2014 Aug 22. Mol Endocrinol. 2014. PMID: 25148457 Free PMC article.
Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mammary tumorigenesis in mice.
Zhang H, Kuang SQ, Liao L, Zhou S, Xu J. Zhang H, et al. Among authors: zhou s. Cancer Res. 2004 Oct 1;64(19):7169-77. doi: 10.1158/0008-5472.CAN-04-1176. Cancer Res. 2004. PMID: 15466215
The coactivator SRC-1 is an essential coordinator of hepatic glucose production.
Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW. Louet JF, et al. Among authors: zhou s. Cell Metab. 2010 Dec 1;12(6):606-18. doi: 10.1016/j.cmet.2010.11.009. Cell Metab. 2010. PMID: 21109193 Free PMC article.
Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.
York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O'Malley BW. York B, et al. Among authors: zhou s. Cell Metab. 2012 May 2;15(5):752-63. doi: 10.1016/j.cmet.2012.03.020. Cell Metab. 2012. PMID: 22560224 Free PMC article.
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