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The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor.
Nakanishi Y, Akiyama N, Tsukaguchi T, Fujii T, Sakata K, Sase H, Isobe T, Morikami K, Shindoh H, Mio T, Ebiike H, Taka N, Aoki Y, Ishii N. Nakanishi Y, et al. Among authors: akiyama n. Mol Cancer Ther. 2014 Nov;13(11):2547-58. doi: 10.1158/1535-7163.MCT-14-0248. Epub 2014 Aug 28. Mol Cancer Ther. 2014. PMID: 25169980
Discovery of [5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Ebiike H, Taka N, Matsushita M, Ohmori M, Takami K, Hyohdoh I, Kohchi M, Hayase T, Nishii H, Morikami K, Nakanishi Y, Akiyama N, Shindoh H, Ishii N, Isobe T, Matsuoka H. Ebiike H, et al. Among authors: akiyama n. J Med Chem. 2016 Dec 8;59(23):10586-10600. doi: 10.1021/acs.jmedchem.6b01156. Epub 2016 Nov 29. J Med Chem. 2016. PMID: 27933954
YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification.
Hamanaka N, Nakanishi Y, Mizuno T, Horiguchi-Takei K, Akiyama N, Tanimura H, Hasegawa M, Satoh Y, Tachibana Y, Fujii T, Sakata K, Ogasawara K, Ebiike H, Koyano H, Sato H, Ishii N, Mio T. Hamanaka N, et al. Among authors: akiyama n. Cancer Res. 2019 Nov 15;79(22):5734-5745. doi: 10.1158/0008-5472.CAN-18-3376. Epub 2019 Aug 7. Cancer Res. 2019. PMID: 31391186
Prognostic impact and risk factors of severe neutropenia in the early phase of treatment with trifluridine-tipiracil for metastatic colorectal cancer patients: a single-center retrospective study.
Omori Y, Matsukuma S, Kawa M, Ishimitsu K, Kawaoka T, Akiyama N, Tokuno K, Fujita Y, Sato S, Yamamoto S. Omori Y, et al. Among authors: akiyama n. Int J Colorectal Dis. 2025 Jan 13;40(1):11. doi: 10.1007/s00384-024-04798-2. Int J Colorectal Dis. 2025. PMID: 39800823 Free PMC article.
Importance of EQA/PT for the detection of genetic variants in comprehensive cancer genome testing.
Matsushita K, Ishige T, Watanabe K, Akahane T, Tanimoto A, Yoshimoto M, Yamakuchi M, Hashiguchi T, Okugawa Y, Ikejiri M, Yamaguchi T, Yamasaki T, Takeda M, Hibi M, Akiyama N, Shimizu K, Hashimoto N, Sato H, Tanaka Y, Amari F; EQA working group of Japan Association for Clinical Laboratory Science(JACLS). Matsushita K, et al. Among authors: akiyama n. Sci Rep. 2025 Jan 7;15(1):1036. doi: 10.1038/s41598-024-84714-4. Sci Rep. 2025. PMID: 39762492 Free PMC article.
439 results